Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.45 |
| ▸ | MMP9 | P14780 | 10/20 | 0.45 |
| ▸ | MMP8 | P22894 | 8/20 | 0.45 |
| ▸ | MMP13 | P45452 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550165 | 0.83 | MMP8 (0.45) | MMP2MMP9MMP8MMP13 | |
| SCHEMBL5443745 | 0.72 | MMP2 (0.70) | MMP2MMP9MMP8MMP13LMNA | |
| SCHEMBL2390775 | 0.68 | MEN1 (0.68) | SMN1; SMN2 | |
| SCHEMBL7477662 | 0.68 | MMP2 (0.60) | MMP2MMP9MMP8MMP13LMNA | |
| SCHEMBL17294160 | 0.68 | MMP2 (0.53) | MMP2MMP9MMP8MMP13LMNA | |
| SCHEMBL6142919 | 0.66 | GRM3 (0.44) | SMN1; SMN2GAAGRM3HSD17B10 | |
| SCHEMBL6142920 | 0.65 | ALDH1A1 (0.45) | LMNASMN1; SMN2GRM3 | |
| SCHEMBL17117354 | 0.65 | POLB (0.61) | SMN1; SMN2 | |
| SCHEMBL542639 | 0.65 | SMN1; SMN2 (0.73) | MMP2MMP9MMP8MMP13LMNA | |
| SCHEMBL6800161 | 0.64 | SIGMAR1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869947-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023465-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-03 | — | — | WO | disclosed |