Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.37 |
| ▸ | HTR1B | P28222 | 11/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551242 | 0.82 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9ACYP1A2 | |
| SCHEMBL8720869 | 0.81 | ACHE (0.39) | HTR1DHTR1BHTR1AHTR1FMEN1 | |
| SCHEMBL7485415 | 0.81 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR1FDRD2 | |
| SCHEMBL8549350 | 0.80 | NPC1 (0.47) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL8550584 | 0.79 | RAB9A (0.41) | HTR1DHTR1BHTR1AHTR1FRAB9A | |
| SCHEMBL8547160 | 0.78 | PNLIP (0.43) | MEN1KMT2ADRD2SLC6A4 | |
| SCHEMBL8551739 | 0.78 | AURKA (0.43) | HTR1DHTR1BHTR1AHTR1FMEN1 | |
| SCHEMBL22252224 | 0.77 | CA12 (0.46) | ACHE | |
| SCHEMBL8550557 | 0.72 | DRD2 (0.43) | HTR1DHTR1BNPC1RAB9AMAPT | |
| SCHEMBL8547605 | 0.70 | RORC (0.45) | HTR1DHTR1BHTR1AHTR1FDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |