Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 7/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181139 | 0.86 | NPC1 (0.48) | HPGDACACBROCK2DYRK1ACLK4 | |
| SCHEMBL8550959 | 0.84 | KDM4E (0.39) | ROCK2RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL8706907 | 0.84 | HPGD (0.42) | HPGDACACBROCK2DYRK1ACLK4 | |
| SCHEMBL8552802 | 0.78 | ROCK1 (0.41) | ROCK2RAB9ANPC1KMT2A | |
| SCHEMBL8552248 | 0.77 | CNR1 (0.47) | HPGDROCK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8549181 | 0.76 | ROCK2 (0.42) | HPGDROCK2KMT2A | |
| SCHEMBL8551076 | 0.74 | CNR2 (0.41) | HPGDRAB9ANPC1KMT2A | |
| SCHEMBL31581176 | 0.71 | HPGD (0.66) | HPGDACACBROCK2DYRK1ACLK4 | |
| SCHEMBL7140235 | 0.70 | ALDH1A1 (0.41) | ROCK2SMN1; SMN2KMT2A | |
| SCHEMBL15243010 | 0.70 | HPGD (0.68) | HPGDACACBROCK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |