Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141725 | 0.85 | ROCK2 (0.43) | ROCK2ROCK1MAPK1PRMT6MEN1 | |
| SCHEMBL8552248 | 0.82 | CNR1 (0.47) | ROCK2ROCK1MEN1KMT2AHPGD | |
| SCHEMBL8552802 | 0.81 | ROCK1 (0.41) | ROCK2ROCK1MEN1KMT2ADHODH | |
| SCHEMBL8550959 | 0.80 | KDM4E (0.39) | ROCK2ROCK1KMT2A | |
| SCHEMBL8550195 | 0.73 | MEN1 (0.44) | ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL8181951 | 0.67 | CNR1 (0.49) | ROCK2ROCK1MEN1KMT2AHPGD | |
| SCHEMBL7138876 | 0.67 | HTR1F (0.45) | ROCK2ROCK1MEN1KMT2ADHODH | |
| SCHEMBL8549583 | 0.66 | HIF1A (0.39) | MEN1KMT2A | |
| SCHEMBL8550329 | 0.66 | KDM4E (0.40) | ROCK2ROCK1 | |
| SCHEMBL8548044 | 0.66 | CNR1 (0.47) | ROCK2ROCK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |