Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8672721 | 0.87 | PTGS2 (0.40) | PTGS2MAPTLMNASMN1; SMN2THRB | |
| SCHEMBL8668966 | 0.87 | SMN1; SMN2 (0.38) | KDM4EPTGS2MAPTLMNARAB9A | |
| SCHEMBL8552372 | 0.86 | PTGS2 (0.36) | PTGS2MAPTLMNASMN1; SMN2THRB | |
| SCHEMBL8547164 | 0.85 | TDP1 (0.38) | KDM4ENCF1MAPTLMNAHSD17B10 | |
| SCHEMBL8550780 | 0.83 | RXRA (0.37) | NCF1L3MBTL1POLB | |
| SCHEMBL8443199 | 0.82 | TDP1 (0.43) | MAPTSMN1; SMN2TSHRHSD17B10POLB | |
| SCHEMBL8441858 | 0.81 | CYP2D6 (0.44) | MAPTPOLB | |
| SCHEMBL8441755 | 0.81 | MEN1 (0.39) | PTGS2MAPTLMNATHRBMEN1 | |
| SCHEMBL8439867 | 0.80 | LMNA (0.44) | LMNASMN1; SMN2POLB | |
| SCHEMBL8441415 | 0.79 | LMNA (0.43) | KDM4ELMNASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708013-A | BENZIMIDAZOLESULFOXIDE DERIVATIVES | EISAI CO., LTD. (JP) | 1998-01-13 | — | — | US | disclosed |