Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8190943 | 0.86 | HTR1F (0.59) | HTR1FMAPTSMN1; SMN2POLB | |
| Maleic Acid SCHEMBL8552223 | 0.86 | HTR1F (0.41) | HTR1FMAPTTP53POLBBCHE | |
| Maleic Acid SCHEMBL8552735 | 0.77 | HDAC1 (0.37) | MAPTTP53BCHE | |
| SCHEMBL8552580 | 0.75 | HTR1F (0.65) | HTR1FMAPTTP53SMN1; SMN2POLB | |
| SCHEMBL8548549 | 0.74 | HTR1F (0.50) | HTR1FMAPTTP53SMN1; SMN2POLB | |
| SCHEMBL8548601 | 0.72 | HTR1F (0.45) | HTR1F | |
| SCHEMBL8548442 | 0.70 | HTR1F (0.48) | HTR1FMAPTTP53SMN1; SMN2 | |
| SCHEMBL8551588 | 0.69 | TMEM97 (0.48) | HTR1FMAPTTP53SMN1; SMN2MCHR1 | |
| Maleic Acid SCHEMBL7143351 | 0.69 | HDAC1 (0.40) | HTR1FSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8552084 | 0.67 | MAPT (0.40) | HTR1FMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |