SCHEMBL8552904

SCHEMBL8552904

N#Cc1cc(Oc2ccnc(OCC(F)(F)F)c2)nc(-c2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.39
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
KIF11 P52732 1/20 0.37
TOP1 P11387 1/20 0.34
LTB4R Q15722 2/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
KDM1A O60341 1/20 0.34
MAOB P27338 1/20 0.34
ADORA1 P30542 2/20 0.34
CETP P11597 1/20 0.33
MAPK1 P28482 1/20 0.33
SCN9A Q15858 1/20 0.33
BRAF P15056 1/20 0.33
KDR P35968 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8553832 0.86 TRPV1 (0.43) TRPV1CTSSCTSKKIF11TOP1
SCHEMBL8553275 0.85 GRM5 (0.41) TRPV1CTSSCTSKKIF11TOP1
SCHEMBL8552758 0.80 KIF11 (0.42) TRPV1CTSSCTSKKIF11MAPK1
SCHEMBL8548872 0.80 POLB (0.43) TRPV1CTSSCTSKKIF11KDM4E
SCHEMBL8549675 0.78 ADORA1 (0.46) TRPV1CTSSCTSKKIF11ADORA1
SCHEMBL8552573 0.77 TRPV1 (0.37) TRPV1CTSSCTSKKIF11MAPK1
SCHEMBL8550852 0.77 KIF11 (0.39) TRPV1CTSSCTSKKIF11MAPK1
SCHEMBL17456814 0.76 CTSS (0.52) CTSSCTSKKIF11TOP1LTB4R
SCHEMBL16013131 0.75 CTSS (0.49) CTSSCTSKKIF11KDM4EMAOB
SCHEMBL8546808 0.74 POLB (0.43) CTSSCTSKKIF11KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0820996-A1 Herbicidal cyanopyridines American Cyanamid Company (US) 1998-01-28 EP claimed
EP-0820996-A1 Herbicidal cyanopyridines American Cyanamid Company (US) 1998-01-28 EP disclosed