Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551585 | 0.92 | SMN1; SMN2 (0.48) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL7707823 | 0.89 | ALOX5 (0.44) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8551933 | 0.88 | PDE3B (0.51) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8551838 | 0.87 | LMNA (0.55) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8557469 | 0.83 | PDE3B (0.52) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8555588 | 0.82 | SMN1; SMN2 (0.47) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8554409 | 0.82 | LMNA (0.47) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL251645 | 0.81 | ALOX5 (0.43) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8554381 | 0.79 | PDE3B (0.48) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA | |
| SCHEMBL8551861 | 0.78 | ALOX5 (0.41) | ALOX5PDE3BPDE3ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |