SCHEMBL251645

SCHEMBL251645

CCCc1[nH]c2cc(C(=O)O)cc(Cc3ccccc3Cl)c2c1C(C)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 2/20 0.40
PTGES O14684 1/20 0.38
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
ALDH1A1 P00352 1/20 0.38
PKM P14618 1/20 0.38
MAPK1 P28482 1/20 0.38
HTT P42858 1/20 0.38
MAPT P10636 1/20 0.35
NR4A2 P43354 2/20 0.35
DOT1L Q8TEK3 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
PPARG P37231 1/20 0.35
CASP6 P55212 1/20 0.35
KDM4A O75164 1/20 0.35
KDM4C Q9H3R0 1/20 0.35
KDM5B Q9UGL1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7707823 0.91 ALOX5 (0.44) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8551585 0.90 SMN1; SMN2 (0.48) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8551861 0.89 ALOX5 (0.41) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL7424550 0.88 ALOX5 (0.39) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8557456 0.84 LMNA (0.48) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8555588 0.82 SMN1; SMN2 (0.47) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8555747 0.82 PLK1 (0.39) ALOX5SMN1; SMN2LMNAPDE3BPDE3A
SCHEMBL8553605 0.81 ALOX5 (0.48) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL8554263 0.81 ALOX5 (0.39) ALOX5SMN1; SMN2LMNAPTGESPDE3B
SCHEMBL6930961 0.81 ALOX5 (0.39) ALOX5SMN1; SMN2LMNAPTGESPDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1624893-A2 INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY Applied Research Systems ARS Holding N.V. (AN) 2006-02-15 EP claimed
WO-2004087211-A2 INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2004-10-14 WO claimed
JP-2003525845-A 2003-09-02 JP claimed
EP-1027054-A4 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS INC (US) 2002-11-04 EP claimed
EP-1237577-A2 TRANSMUCOSAL COMPOSITION CONTAINING A PHOSPHODIESTERASE INHIBITOR FOR THE TREATMENT OF ERECTILE DYSFUNCTION Vivus, Inc. (US) 2002-09-11 EP claimed
WO-2001070211-A2 L-ARGININE AND PHOSPHODIESTERASE (PDE) INHIBITOR SYNERGISM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-09-27 WO claimed
WO-2001041807-A2 TRANSMUCOSAL COMPOSITION CONTAINING A PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS, INC. (US) 2001-06-14 WO claimed
EP-1027054-A1 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION Vivus, Inc. (US) 2000-08-16 EP claimed
WO-1999021558-A2 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS, INC. (US) 1999-05-06 WO claimed
WO-2018132371-A2 METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION UNITED THERAPEUTICS CORPORATION (US) 2018-07-19 WO disclosed
WO-2013067309-A1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF MELANOCORTIN RECEPTOR AGONIST COMPOUNDS XION PHARMACEUTICAL CORPORATION (US) 2013-05-10 WO disclosed
EP-2512479-A1 METHODS AND COMPOSITIONS FOR TREATING PERIPHERAL VASCULAR DISEASE Exodos Life Sciences Limited Partnership (US) 2012-10-24 EP disclosed
EP-2401279-A1 1, 4-DISUBSTITUTED PIPERIDINES AS VASOPRESSIN RECEPTOR VIA ANTAGONISTS Vantia Limited (GB) 2012-01-04 EP disclosed
WO-2011075655-A1 METHODS AND COMPOSITIONS FOR TREATING PERIPHERAL VASCULAR DISEASE EXODOS LIFE SCIENCES LIMITED PARTNERSHIP (US) 2011-06-23 WO disclosed
WO-2002019213-A2 METHOD FOR TREATMENT OF MIGRAINE USING PDE5 INHIBITORS LILLY ICOS LLC (US) 2002-03-07 WO disclosed
WO-2002017927-A1 METHOD FOR TREATING ERECTILE DYSFUNCTION AND INCREASING LIBIDO IN MEN UNIMED PHARMACEUTICALS, INC. (US) 2002-03-07 WO disclosed
WO-2001070211-A2 L-ARGININE AND PHOSPHODIESTERASE (PDE) INHIBITOR SYNERGISM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-09-27 WO disclosed
EP-1027057-A1 TREATMENT OF FEMALE SEXUAL DYSFUNCTION Asivi, LLC (US) 2000-08-16 EP disclosed
WO-1999021562-A1 TREATMENT OF FEMALE SEXUAL DYSFUNCTION ASIVI, LLC (US) 1999-05-06 WO disclosed
EP-0820441-A1 INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-01-28 EP disclosed