SCHEMBL8554066

SCHEMBL8554066

Cc1cccc(O)c1-n1c(Cl)nn(C)c1=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.35
ATM Q13315 1/20 0.35
ALDH1A1 P00352 3/20 0.35
POLB P06746 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
ANPEP P15144 1/20 0.34
DPP4 P27487 1/20 0.34
ADRA2A P08913 1/20 0.32
DRD4 P21917 1/20 0.32
HRH2 P25021 1/20 0.32
HTR7 P34969 1/20 0.32
OPRK1 P41145 1/20 0.32
HTR2B P41595 1/20 0.32
SLC6A3 Q01959 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
EPHB4 P54760 1/20 0.31
MAPK13 O15264 1/20 0.31
MAPK12 P53778 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8484527 0.81 HPGD (0.37) ALDH1A1POLBMEN1KMT2ASMN1; SMN2
SCHEMBL8483159 0.79 BRD9 (0.37) TRPA1ATMALDH1A1POLBMEN1
SCHEMBL8499784 0.79 ALDH1A1 (0.36) ALDH1A1POLBMEN1KMT2AMAPK14
SCHEMBL8343534 0.79 APLNR (0.43) ALDH1A1POLBMEN1KMT2AL3MBTL1
SCHEMBL8486957 0.78 ALDH1A1 (0.35) ALDH1A1POLBMEN1KMT2AMAPK14
SCHEMBL8480846 0.78 ALDH1A1 (0.41) ALDH1A1POLBSLC6A3L3MBTL1KDM4E
SCHEMBL8590523 0.76 KDM4E (0.47) ALDH1A1POLBMEN1KMT2AL3MBTL1
SCHEMBL6603431 0.74 HCAR1 (0.48) ALDH1A1MEN1KMT2AHTR7L3MBTL1
SCHEMBL8862152 0.72 MAPT (0.41) ALDH1A1KMT2AL3MBTL1SMN1; SMN2MAPK14
SCHEMBL13045968 0.69 GABRA1 (0.45) ALDH1A1POLBMEN1KMT2AANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0836384-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-04-22 EP claimed
WO-1997000612-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-09 WO claimed
WO-1998023155-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-06-04 WO disclosed
EP-0836384-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-04-22 EP disclosed
WO-1997000612-A1 ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-09 WO disclosed