SCHEMBL8480846

SCHEMBL8480846

COC(=O)c1cccc(C)c1-n1c(Cl)nn(C)c1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 4/20 0.41
HTT P42858 2/20 0.41
GLA P06280 1/20 0.41
HPGD P15428 1/20 0.41
MYC P01106 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
NR4A2 P43354 1/20 0.37
TSHR P16473 2/20 0.37
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
MAPK1 P28482 1/20 0.36
LCK P06239 1/20 0.36
PTGS2 P35354 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
LMNA P02545 2/20 0.36
BRD4 O60885 1/20 0.35
POLB P06746 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8481561 0.80 MYC (0.56) ALDH1A1KDM4EMYCNR4A2TSHR
SCHEMBL8343534 0.79 APLNR (0.43) ALDH1A1KDM4EL3MBTL1MAPTPOLB
SCHEMBL8554066 0.78 TRPA1 (0.35) ALDH1A1KDM4EGLAL3MBTL1MAPT
SCHEMBL11663681 0.74 ALDH1A1 (0.47) ALDH1A1KDM4EHTTGLAHPGD
SCHEMBL8104540 0.71 ALDH1A1 (0.33) ALDH1A1KDM4EHTTHPGDMYC
SCHEMBL10103507 0.70 HTR7 (0.47) ALDH1A1KDM4EHTTGLAHPGD
SCHEMBL2196615 0.69 PTGS2 (0.55) ALDH1A1KDM4EHTTMYCL3MBTL1
SCHEMBL8484934 0.67 MYC (0.56) ALDH1A1KDM4EMYCNR4A2TSHR
SCHEMBL524457 0.65 LMNA (0.53) ALDH1A1KDM4EMYCL3MBTL1NR4A2
SCHEMBL5745278 0.65 ALDH1A1 (0.53) ALDH1A1KDM4EHTTGLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962436-A AGRICULTURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-10-05 US disclosed
WO-1996026191-A1 FUNGICIDAL CYCLIC AMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-08-29 WO disclosed