Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CTSG | P08311 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8598630 | 0.96 | MEN1 (0.34) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL8559143 | 0.95 | GPR84 (0.36) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL8556983 | 0.93 | DHFR (0.37) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL8556883 | 0.89 | PDK2 (0.40) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL8560875 | 0.81 | MEN1 (0.36) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL8557438 | 0.72 | PDK2 (0.42) | MEN1KMT2AMAPTPDK2ELANE | |
| SCHEMBL8556692 | 0.70 | KDM4E (0.36) | MEN1KMT2APOLBKDM4EMAPT | |
| SCHEMBL8555558 | 0.70 | GABRA1 (0.42) | MEN1KMT2APOLBGAAKDM4E | |
| SCHEMBL14318839 | 0.70 | ALOX5 (0.49) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL8559099 | 0.69 | TYR (0.44) | MEN1KMT2AMAPTPDK2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |