Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554202 | 0.93 | MEN1 (0.35) | DHFRMEN1KMT2AGAAPOLB | |
| SCHEMBL8598630 | 0.91 | MEN1 (0.34) | MEN1KMT2AGAAPOLBKDM4E | |
| SCHEMBL8556883 | 0.91 | PDK2 (0.40) | MEN1KMT2AGAAPOLBKDM4E | |
| SCHEMBL8559143 | 0.90 | GPR84 (0.36) | MEN1KMT2AGAAPOLBKDM4E | |
| SCHEMBL8560875 | 0.83 | MEN1 (0.36) | MEN1KMT2AGAAPOLBKDM4E | |
| SCHEMBL8555558 | 0.71 | GABRA1 (0.42) | MEN1KMT2AGAAPOLBKDM4E | |
| SCHEMBL8556960 | 0.71 | PDK2 (0.44) | PDK2ALOX5 | |
| SCHEMBL8560521 | 0.69 | ALDH1A1 (0.35) | GAAKDM4EHPGDALDH1A1GLA | |
| SCHEMBL8560283 | 0.68 | KDM4E (0.37) | MEN1KMT2AGAAKDM4EPDK2 | |
| SCHEMBL8559665 | 0.68 | PDK2 (0.33) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |