Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553880 | 0.80 | L3MBTL1 (0.64) | TSHRL3MBTL1SIRT2SIRT1MEN1 | |
| SCHEMBL5338561 | 0.79 | TSHR (0.71) | TSHRL3MBTL1MEN1KMT2ACHRM1 | |
| SCHEMBL28663777 | 0.76 | GSK3B (0.53) | TSHRGSK3BACHEMEN1KMT2A | |
| SCHEMBL13150794 | 0.75 | TSHR (0.66) | TSHRL3MBTL1SIRT2SIRT1MEN1 | |
| SCHEMBL8557086 | 0.74 | TSHR (0.67) | TSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL8553215 | 0.74 | TSHR (0.67) | TSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL7358743 | 0.72 | ALDH1A1 (0.61) | TSHRL3MBTL1MEN1KMT2ADRD4 | |
| SCHEMBL7114927 | 0.71 | ACHE (0.56) | TSHRGSK3BACHEMEN1KMT2A | |
| SCHEMBL474614 | 0.71 | TSHR (0.60) | TSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL18954615 | 0.70 | ACHE (0.73) | GSK3BACHECHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |