Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555239 | 0.87 | MAPT (0.48) | HPGDALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL8557997 | 0.87 | AR (0.51) | HPGDMAPTTSHRNPSR1GAA | |
| SCHEMBL8553642 | 0.85 | AR (0.46) | HPGDALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL8558890 | 0.85 | CCR2 (0.41) | ALDH1A1MAPT | |
| SCHEMBL8560966 | 0.85 | AR (0.48) | MAPTNPSR1GRM5SLC40A1PTPN2 | |
| SCHEMBL8558438 | 0.83 | HPGD (0.41) | HPGDALDH1A1SMN1; SMN2RECQLMAPT | |
| SCHEMBL8560603 | 0.82 | GRM5 (0.44) | MAPTNPSR1GRM5SLC40A1PTPN2 | |
| SCHEMBL8556744 | 0.82 | GRM5 (0.44) | GRM5SLC40A1PTPN2PTPN1PTPN5 | |
| SCHEMBL9025890 | 0.81 | AR (0.45) | GRM5PTPN1 | |
| SCHEMBL8557266 | 0.80 | AR (0.51) | HPGDMAPTTSHRLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |