Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556135 | 0.87 | MAPT (0.48) | HPGDALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL8555123 | 0.87 | AR (0.51) | HPGDMAPTTSHRGAANPSR1 | |
| SCHEMBL8561913 | 0.85 | AR (0.46) | HPGDALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL8555566 | 0.85 | CCR2 (0.41) | ALDH1A1LMNAKDM4EHSD17B10KMT2A | |
| SCHEMBL8555993 | 0.83 | HPGD (0.46) | HPGDALDH1A1SMN1; SMN2RECQLMAPT | |
| SCHEMBL8559033 | 0.82 | GRM5 (0.44) | MAPTGRM5PTPN2PTPN1PTPN5 | |
| SCHEMBL9026048 | 0.81 | MEN1 (0.50) | GRM5PTPN1MEN1KMT2A | |
| SCHEMBL8557604 | 0.80 | AR (0.51) | HPGDALDH1A1TSHRGAAMAPK1 | |
| SCHEMBL9025550 | 0.80 | AR (0.46) | HPGDALDH1A1SMN1; SMN2MAPTTSHR | |
| SCHEMBL8554235 | 0.79 | MEN1 (0.45) | HPGDTSHRGAAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |