Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 2/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556146 | 0.91 | PGR (0.50) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8560337 | 0.90 | MAPT (0.50) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8557471 | 0.88 | MAPT (0.48) | MAPTALDH1A1LMNAKDM4ERXFP1 | |
| SCHEMBL8560000 | 0.87 | KMO (0.47) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8555551 | 0.86 | MAPT (0.43) | MAPTALDH1A1LMNAKDM4ERXFP1 | |
| SCHEMBL8557996 | 0.86 | MAPT (0.46) | MAPTALDH1A1LMNAGAANPSR1 | |
| SCHEMBL8555914 | 0.85 | MAPT (0.43) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8560392 | 0.85 | MAPT (0.44) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8554941 | 0.84 | MAPT (0.41) | MAPTALDH1A1LMNAPGRKDM4E | |
| SCHEMBL8559699 | 0.84 | MAPT (0.43) | MAPTALDH1A1LMNAPGRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |