Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026498 | 0.96 | MAPT (0.43) | MAPTPOLBALDH1A1LMNATSHR | |
| SCHEMBL8560019 | 0.92 | MAPT (0.43) | MAPTPOLBALDH1A1LMNATSHR | |
| SCHEMBL8560000 | 0.91 | KMO (0.47) | MAPTALDH1A1LMNATSHRKDM4E | |
| SCHEMBL8558253 | 0.91 | ALDH1A1 (0.44) | MAPTPOLBALDH1A1LMNATSHR | |
| SCHEMBL8558562 | 0.88 | MAPT (0.43) | MAPTALDH1A1LMNATSHRKDM4E | |
| SCHEMBL8560184 | 0.87 | MAPT (0.46) | MAPTPOLBALDH1A1LMNATSHR | |
| SCHEMBL8559236 | 0.86 | KMT2A (0.47) | MAPTALDH1A1LMNATSHRKDM4E | |
| SCHEMBL8555756 | 0.85 | MAPT (0.46) | MAPTPOLBALDH1A1LMNATSHR | |
| SCHEMBL8560574 | 0.85 | MAPT (0.46) | MAPTALDH1A1LMNATSHRKDM4E | |
| SCHEMBL8560337 | 0.85 | MAPT (0.50) | MAPTPOLBALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |