Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557471 | 0.92 | MAPT (0.48) | MAPTALDH1A1LMNALIMK2MEN1 | |
| SCHEMBL8556039 | 0.90 | MAPT (0.44) | MAPTALDH1A1LMNAKDM1ALIMK2 | |
| SCHEMBL8559708 | 0.88 | MAPT (0.46) | MAPTALDH1A1LIMK2MEN1KMT2A | |
| SCHEMBL8560574 | 0.88 | MAPT (0.46) | MAPTALDH1A1LMNALIMK2MEN1 | |
| SCHEMBL8556146 | 0.88 | PGR (0.50) | MAPTALDH1A1LMNAKDM1AGAA | |
| SCHEMBL8560000 | 0.88 | KMO (0.47) | MAPTALDH1A1LMNALIMK2MEN1 | |
| SCHEMBL8556972 | 0.85 | ALDH1A1 (0.49) | MAPTALDH1A1LMNAKMT2APOLB | |
| SCHEMBL8554941 | 0.85 | MAPT (0.41) | MAPTALDH1A1LMNALIMK2KMT2A | |
| SCHEMBL8559699 | 0.85 | MAPT (0.43) | MAPTALDH1A1LMNALIMK2GAA | |
| SCHEMBL8560019 | 0.85 | MAPT (0.43) | MAPTALDH1A1LMNALIMK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |