Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557474 | 0.88 | HSD11B1 (0.48) | HSD11B1OPRM1OPRK1OPRL1TSHR | |
| SCHEMBL7464929 | 0.85 | HSD11B1 (0.57) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL8870741 | 0.84 | TSHR (0.50) | HSD11B1TSHRSLC6A4HTR1A | |
| SCHEMBL5340537 | 0.83 | HSD11B1 (0.68) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL18324763 | 0.82 | KDM4E (0.69) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL9541312 | 0.81 | TSHR (0.60) | TSHRSLC6A4HTR1A | |
| SCHEMBL8870996 | 0.81 | TSHR (0.47) | HSD11B1TSHRSLC6A4HTR1AHTR7 | |
| SCHEMBL6347867 | 0.79 | HSD11B1 (0.76) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL10922885 | 0.79 | HSD11B1 (0.66) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL8557211 | 0.78 | KMT2A (0.52) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047385-C | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1999-12-15 | — | — | CN | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |