Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.52 |
| ▸ | NMT2 | O60551 | 1/20 | 0.51 |
| ▸ | NMT1 | P30419 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556742 | 0.85 | HSD11B1 (0.61) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL5340537 | 0.80 | HSD11B1 (0.68) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| Hydrochloric Acid SCHEMBL9049559 | 0.79 | OPRM1 (0.59) | OPRM1OPRK1OPRL1SLC6A4HTR1A | |
| SCHEMBL18324763 | 0.79 | KDM4E (0.69) | HSD11B1OPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL27510903 | 0.77 | HSD11B1 (0.51) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL6347867 | 0.76 | HSD11B1 (0.76) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL10922885 | 0.75 | HSD11B1 (0.66) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL18324845 | 0.75 | DRD2 (0.61) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL8557474 | 0.75 | HSD11B1 (0.48) | HSD11B1OPRM1OPRK1OPRL1CCR2 | |
| SCHEMBL22605559 | 0.74 | ALDH1A1 (0.58) | HSD11B1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708102-B1 | 5-HT1F agonists for the treatment of migraine | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| US-5721252-A | PIPERIDINYL-1H-INDOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| US-5521196-A | ANALGESICS USING SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |