Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 9/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556742 | 0.81 | HSD11B1 (0.61) | TSHRSLC6A4HTR1A | |
| SCHEMBL23244251 | 0.81 | ME2 (0.59) | TSHRMPOACHESLC6A4HTR1A | |
| SCHEMBL9541243 | 0.78 | MPO (0.76) | MPOSLC6A4HTR1A | |
| SCHEMBL8870741 | 0.77 | TSHR (0.50) | TSHRPTGDR2MPOGPR84ACHE | |
| SCHEMBL13952937 | 0.77 | TSHR (0.45) | TSHRPTGDR2MPOACHESLC6A4 | |
| SCHEMBL29577224 | 0.77 | TDO2 (0.55) | TSHRACHESLC6A4 | |
| SCHEMBL23244324 | 0.77 | TDO2 (0.55) | TSHRACHESLC6A4 | |
| SCHEMBL2260803 | 0.76 | TSHR (1.00) | TSHRMPOGPR84SLC6A4HTR1A | |
| SCHEMBL15245611 | 0.75 | TSHR (0.56) | TSHRMPOGPR84SLC6A4HTR1A | |
| SCHEMBL8557474 | 0.75 | HSD11B1 (0.48) | TSHRPTGDR2SLC6A4HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014084-A2 | PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-07-22 | — | — | WO | disclosed |