Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 3/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557474 | 0.91 | HSD11B1 (0.48) | KCNH2SLC6A4HTR7HTR1AHSD11B1 | |
| SCHEMBL8871409 | 0.85 | KMT2A (0.51) | KMT2ALMNAKCNH2SLC6A4HTR7 | |
| SCHEMBL8558619 | 0.84 | HTR1A (0.62) | KCNH2SLC6A4HTR7HTR1AMPO | |
| SCHEMBL8554029 | 0.82 | HTR1A (0.70) | KCNH2SLC6A4HTR7HTR1AMPO | |
| SCHEMBL8871407 | 0.79 | KMT2A (0.48) | KMT2ALMNASLC6A4HTR1AMPO | |
| SCHEMBL8556742 | 0.78 | HSD11B1 (0.61) | SLC6A4HTR7HTR1AHSD11B1HTR6 | |
| SCHEMBL27319887 | 0.78 | OPRM1 (0.45) | KCNH2SLC6A4HTR7HTR1AHTR6 | |
| SCHEMBL11349537 | 0.77 | MPO (0.56) | KMT2ALMNAKCNH2SLC6A4HTR7 | |
| SCHEMBL8870996 | 0.75 | TSHR (0.47) | KCNH2SLC6A4HTR7HTR1AHSD11B1 | |
| SCHEMBL18324728 | 0.75 | ALDH1A1 (0.65) | SLC6A4HTR1AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047385-C | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1999-12-15 | — | — | CN | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |