Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | HTR1F | P30939 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557211 | 0.91 | KMT2A (0.52) | HSD11B1OPRM1OPRK1OPRL1HTR1A | |
| SCHEMBL8556742 | 0.88 | HSD11B1 (0.61) | HSD11B1TSHROPRM1OPRK1OPRL1 | |
| SCHEMBL8870996 | 0.84 | TSHR (0.47) | HSD11B1TSHRPTGDR2HTR1AKCNH2 | |
| SCHEMBL8558619 | 0.82 | HTR1A (0.62) | OPRM1OPRK1OPRL1HTR1AKCNH2 | |
| SCHEMBL8554029 | 0.80 | HTR1A (0.70) | HTR1AKCNH2SLC6A4HTR7HTR6 | |
| SCHEMBL27319887 | 0.79 | OPRM1 (0.45) | OPRM1OPRK1OPRL1HTR1AKCNH2 | |
| SCHEMBL8870992 | 0.79 | TSHR (0.47) | HSD11B1TSHRPTGDR2HTR1ASLC6A4 | |
| SCHEMBL8870741 | 0.78 | TSHR (0.50) | HSD11B1TSHRPTGDR2HTR1ASLC6A4 | |
| SCHEMBL18324728 | 0.76 | ALDH1A1 (0.65) | HSD11B1HTR1ASLC6A4CCR2HTR1F | |
| SCHEMBL27318962 | 0.76 | HTR1A (0.44) | HSD11B1OPRM1OPRK1OPRL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047385-C | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1999-12-15 | — | — | CN | disclosed |
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| CN-1114651-A | 3-indolylpiperidine | MERCK PATENT GMBH (DE) | 1996-01-10 | — | — | CN | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |