Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.41 |
| ▸ | FEN1 | P39748 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558565 | 0.92 | PTGS2 (0.44) | PTGS2PTGS1ALOX5APFEN1TP53 | |
| SCHEMBL8556992 | 0.92 | PTGS1 (0.40) | PTGS2PTGS1ALOX5APFEN1TP53 | |
| SCHEMBL8561401 | 0.91 | MAOB (0.41) | PTGS2PTGS1TP53MAPTMAOB | |
| SCHEMBL8557992 | 0.91 | ALOX5AP (0.41) | PTGS2PTGS1ALOX5APFEN1MAOB | |
| SCHEMBL8559262 | 0.88 | NR4A2 (0.40) | PTGS2PTGS1MAPTMAOBRXRA | |
| SCHEMBL8561414 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8556529 | 0.87 | RXRA (0.40) | PTGS2PTGS1ALOX5APFEN1RXRA | |
| SCHEMBL8555605 | 0.87 | RXRA (0.44) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8558066 | 0.86 | NR4A2 (0.40) | PTGS2PTGS1MAPTMAOBRXRA | |
| SCHEMBL7509029 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1TP53MAPTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |