Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 3/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557438 | 0.91 | PDK2 (0.42) | PDK2ELANECTSGDRD2DRD1 | |
| SCHEMBL8559099 | 0.90 | TYR (0.44) | PDK2ELANECTSGALOX5TYR | |
| SCHEMBL8557956 | 0.88 | TYR (0.47) | PDK2ELANECTSGALOX5TYR | |
| SCHEMBL8552847 | 0.75 | ALDH1A1 (0.41) | PDK2ELANECTSGPDK4PDK1 | |
| SCHEMBL8560283 | 0.73 | KDM4E (0.37) | PDK2 | |
| SCHEMBL8556983 | 0.71 | DHFR (0.37) | PDK2ALOX5 | |
| SCHEMBL3150359 | 0.64 | PDK2 (0.52) | PDK2DRD1PDK4PDK1PDK3 | |
| SCHEMBL8556238 | 0.64 | PDK2 (0.34) | PDK2ELANEPDK4PDK1PDK3 | |
| SCHEMBL10828239 | 0.62 | PDK2 (0.61) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL31528161 | 0.62 | CNR2 (0.39) | PDK2ELANECTSGDRD1PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |