SCHEMBL8557845

SCHEMBL8557845

CCOC(=O)c1ccccc1NC(=S)c1ccc(OC)nc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.52
HSD17B10 Q99714 4/20 0.52
LMNA P02545 2/20 0.52
TP53 P04637 2/20 0.52
ALDH1A1 P00352 8/20 0.52
KMT2A Q03164 4/20 0.52
POLB P06746 2/20 0.52
MEN1 O00255 2/20 0.52
MAPT P10636 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
HPGD P15428 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
TSHR P16473 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
MAPK10 P53779 1/20 0.49
ATM Q13315 1/20 0.48
MAPK1 P28482 1/20 0.47
TDP1 Q9NUW8 2/20 0.47
HTT P42858 1/20 0.47
ELANE P08246 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8557467 0.90 LMNA (0.53) KDM4EHSD17B10LMNAALDH1A1KMT2A
SCHEMBL8559131 0.88 ALDH1A1 (0.47) KDM4EHSD17B10LMNATP53ALDH1A1
SCHEMBL13720914 0.80 TSHR (0.55) KDM4EHSD17B10LMNATP53ALDH1A1
SCHEMBL8554348 0.77 TSHR (0.61) KDM4EHSD17B10LMNATP53ALDH1A1
SCHEMBL10972399 0.76 NNMT (0.60) KDM4ELMNAKMT2AMEN1MAPT
SCHEMBL8559233 0.75 LMNA (0.56) KDM4EHSD17B10LMNAALDH1A1KMT2A
SCHEMBL3644661 0.73 KDM4E (0.63) KDM4EHSD17B10LMNATP53ALDH1A1
SCHEMBL8564208 0.72 CHEK1 (0.61) LMNAALDH1A1KMT2APOLBMEN1
SCHEMBL7522563 0.72 KDM4E (0.67) KDM4EHSD17B10LMNATP53ALDH1A1
SCHEMBL8560123 0.72 CHEK1 (0.60) LMNAALDH1A1KMT2APOLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756524-A APPLYING TO COMBAT CYTOPATHOGENIC FUNGI AGREVO UK LIMITED (GB) 1998-05-26 US disclosed
EP-0750611-A1 ANILIDE DERIVATIVES AS FUNGICIDES AgrEvo UK Limited (GB) 1997-01-02 EP disclosed
WO-1995025723-A1 ANILIDE DERIVATIVES AS FUNGICIDES AGREVO UK LIMITED (GB) 1995-09-28 WO disclosed