Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755650 | 0.89 | MMP8 (0.41) | GRIN2BSMN1; SMN2MMP8MAPTTDP1 | |
| SCHEMBL9954167 | 0.78 | CYP1A2 (0.43) | SMN1; SMN2MAPTALDH1A1CTSLCTSS | |
| SCHEMBL12203627 | 0.76 | ALDH1A1 (0.36) | SIGMAR1SMN1; SMN2ALDH1A1CTSLTSHR | |
| SCHEMBL27892076 | 0.76 | CYP1A2 (0.42) | SMN1; SMN2MAPTALDH1A1CTSLCTSS | |
| SCHEMBL14999473 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTCTSLCTSSCTSK | |
| SCHEMBL19124635 | 0.73 | KDM4E (0.41) | SMN1; SMN2MAPTTDP1CTSLCTSS | |
| SCHEMBL9260996 | 0.72 | PLK1 (0.35) | SIGMAR1SMN1; SMN2ALDH1A1CTSLCTSS | |
| SCHEMBL8557856 | 0.72 | PLK1 (0.35) | SIGMAR1SMN1; SMN2ALDH1A1CTSLCTSS | |
| SCHEMBL8556244 | 0.72 | SIGMAR1 (0.41) | SIGMAR1GRIN2BMMP8MAPTTDP1 | |
| SCHEMBL9232122 | 0.71 | OPRM1 (0.58) | SIGMAR1SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635497-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR (FR) | 1998-05-20 | — | — | EP | disclosed |
| US-5436261-A | Adrenergic agonists | ADIR ET COMPAGNIE (FR) | 1995-07-25 | — | — | US | disclosed |
| EP-0635497-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |