Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559724 | 0.85 | AVPR2 (0.51) | SMN1; SMN2HPGDRAB9AAVPR2AVPR1A | |
| SCHEMBL8562104 | 0.81 | HPGD (0.58) | SMN1; SMN2HPGDRAB9AL3MBTL1KMT2A | |
| SCHEMBL5236488 | 0.81 | AVPR2 (0.49) | SMN1; SMN2HPGDRAB9AAVPR2AVPR1A | |
| SCHEMBL8561524 | 0.80 | HPGD (0.46) | SMN1; SMN2HPGDRAB9AAVPR2AVPR1A | |
| SCHEMBL6994753 | 0.80 | AVPR2 (0.45) | SMN1; SMN2HPGDRAB9AAVPR2AVPR1A | |
| SCHEMBL7352575 | 0.78 | ALDH1A1 (0.56) | HPGDRAB9AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL21160915 | 0.78 | HPGD (0.49) | SMN1; SMN2HPGDRAB9AL3MBTL1KMT2A | |
| SCHEMBL8561256 | 0.77 | HPGD (0.48) | SMN1; SMN2HPGDRAB9AL3MBTL1KMT2A | |
| SCHEMBL8820731 | 0.77 | AVPR1A (0.63) | AVPR2AVPR1A | |
| SCHEMBL8819120 | 0.77 | AVPR2 (0.75) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |