Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561104 | 0.84 | AVPR2 (0.53) | HPGDL3MBTL1P2RX4ALDH1A1NPC1 | |
| SCHEMBL8562104 | 0.83 | HPGD (0.58) | HPGDL3MBTL1ALDH1A1MAPTNPC1 | |
| SCHEMBL7352575 | 0.79 | ALDH1A1 (0.56) | HPGDL3MBTL1P2RX4ALDH1A1MAPT | |
| SCHEMBL8561524 | 0.78 | HPGD (0.46) | HPGDL3MBTL1ALDH1A1MAPTNPC1 | |
| SCHEMBL8558397 | 0.77 | SMN1; SMN2 (0.47) | HPGDL3MBTL1ALDH1A1MAPTNPC1 | |
| SCHEMBL6990464 | 0.76 | ALDH1A1 (0.52) | HPGDL3MBTL1P2RX4ALDH1A1MAPT | |
| SCHEMBL20599103 | 0.75 | L3MBTL1 (0.48) | HPGDL3MBTL1ALDH1A1MAPTNPC1 | |
| SCHEMBL7345718 | 0.75 | ALDH1A1 (0.49) | HPGDL3MBTL1P2RX4ALDH1A1MAPT | |
| SCHEMBL19078673 | 0.75 | L3MBTL1 (0.48) | HPGDL3MBTL1ALDH1A1MAPTNPC1 | |
| SCHEMBL21160915 | 0.75 | HPGD (0.49) | HPGDL3MBTL1P2RX4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |