Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561913 | 0.93 | AR (0.46) | ARALDH1A1MAPTAURKALMNA | |
| SCHEMBL8557471 | 0.90 | MAPT (0.48) | LIMK2ALDH1A1MAPTAURKALMNA | |
| SCHEMBL8555123 | 0.86 | AR (0.51) | ARMAPTKDM4ENPC1RAB9A | |
| SCHEMBL8557604 | 0.86 | AR (0.51) | ARALDH1A1KDM4EPOLBBCL2L1 | |
| SCHEMBL8554235 | 0.84 | MEN1 (0.45) | ARPTGER4BCL2L1MCL1TDP1 | |
| SCHEMBL8556972 | 0.84 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8561015 | 0.83 | MAPT (0.48) | ALDH1A1MAPTPTGES2LMNASMN1; SMN2 | |
| SCHEMBL8555920 | 0.83 | PGR (0.46) | MAPTLMNAKDM4EPOLBPGR | |
| SCHEMBL8559033 | 0.83 | GRM5 (0.44) | ARMAPTPGR | |
| SCHEMBL9025133 | 0.83 | AR (0.46) | ARLIMK2ALDH1A1MAPTPTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |