Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.51 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316932 | 0.74 | F2 (0.51) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL2490664 | 0.73 | SIGMAR1 (0.57) | — | |
| SCHEMBL6943882 | 0.73 | ALDH1A1 (0.51) | F2 | |
| SCHEMBL27351409 | 0.72 | F2 (0.53) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL8030987 | 0.72 | ALDH1A1 (0.68) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL3696484 | 0.72 | CHKA (0.42) | — | |
| SCHEMBL8579991 | 0.70 | NOX4 (0.41) | — | |
| SCHEMBL27350108 | 0.70 | F2 (0.55) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL7316048 | 0.69 | F2 (0.75) | F2PRSS1PRSS3PRSS2TMPRSS6 | |
| SCHEMBL2403330 | 0.69 | F2 (1.00) | F2PRSS1PRSS3PRSS2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825994-A1 | AMIDINE DERIVATIVES USEFUL AS ANTI-PLATELET AGGREGATION INHIBITORS AND VASODILATORS | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036639-A1 | AMIDINE DERIVATIVES USEFUL AS ANTI-PLATELET AGGREGATION INHIBITORS AND VASODILATORS | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |