Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025121 | 0.93 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNASLC40A1POLB | |
| SCHEMBL8561122 | 0.88 | MAPT (0.44) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8556104 | 0.87 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8559468 | 0.86 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8559393 | 0.85 | KMO (0.47) | ALDH1A1MAPTLMNATSHRSLC40A1 | |
| SCHEMBL8557926 | 0.85 | LMNA (0.49) | ALDH1A1MAPTLMNATSHRSLC40A1 | |
| SCHEMBL8555983 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8559259 | 0.85 | MAPT (0.47) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8555914 | 0.84 | MAPT (0.43) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL9025116 | 0.84 | MAPT (0.42) | ALDH1A1MAPTLMNATSHRSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |