Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594274 | 0.82 | NNMT (0.48) | JUNNFKB1NFKB2RELANPSR1 | |
| SCHEMBL16454401 | 0.81 | JUN (0.43) | MAPTJUNNFKB1NFKB2RELA | |
| SCHEMBL17796812 | 0.79 | MAPT (0.45) | MAPTJUNNFKB1NFKB2RELA | |
| SCHEMBL17808271 | 0.79 | MAPT (0.40) | MAPTJUNNFKB1NFKB2RELA | |
| SCHEMBL16119847 | 0.78 | MAPK8 (0.33) | JUNNFKB1NFKB2RELAMAPK8 | |
| SCHEMBL18699191 | 0.75 | MAPT (0.37) | MAPTJUNNFKB1NFKB2RELA | |
| SCHEMBL8722111 | 0.73 | NFKB1 (0.60) | MAPTJUNNFKB1NFKB2RELA | |
| SCHEMBL20772274 | 0.70 | ALDH1A1 (0.40) | MAPTPOLBALDH1A1ASPHAR | |
| SCHEMBL23775233 | 0.70 | NNMT (0.62) | MAPTKDM4EPOLBALDH1A1NPSR1 | |
| SCHEMBL16455673 | 0.70 | POLB (0.47) | MAPTJUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |