Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.72 |
| ▸ | MMP1 | P03956 | 19/20 | 0.72 |
| ▸ | MMP9 | P14780 | 17/20 | 0.72 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929880 | 0.85 | MMP1 (0.76) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL6928874 | 0.84 | MMP1 (1.00) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL8560568 | 0.80 | MMP9 (0.51) | MMP13MMP1MMP9MMP2 | |
| SCHEMBL27570064 | 0.78 | MMP1 (0.64) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL8436167 | 0.78 | MMP13 (0.54) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL6928530 | 0.78 | MMP13 (1.00) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7638340 | 0.78 | MMP1 (0.64) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL6932195 | 0.77 | MMP13 (0.63) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL7516170 | 0.77 | GAA (0.49) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL6934151 | 0.76 | MMP13 (0.68) | MMP13MMP1MMP9MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804593-A | FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. | PHARMACIA & UPJOHN COMPANY (US) | 1998-09-08 | — | — | US | disclosed |