Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559644 | 0.81 | MAPT (0.53) | MAPTTP53CTSDBACE1HPGD | |
| SCHEMBL8565253 | 0.79 | NQO1 (0.50) | MAPTHRH3PDGFRBPDGFRAHDAC1 | |
| SCHEMBL8565804 | 0.78 | HPGD (0.43) | MAPTTP53CTSDBACE1RXFP1 | |
| SCHEMBL23457529 | 0.71 | HTR3A (0.35) | HTR3AHRH4CTSDBACE1HRH3 | |
| SCHEMBL29699567 | 0.71 | HTR3A (0.35) | HTR3AHRH4CTSDBACE1HRH3 | |
| SCHEMBL4580401 | 0.68 | MAOA (0.56) | MAPTTP53CYP2A6HPGD | |
| SCHEMBL4066225 | 0.68 | SLC6A4 (0.47) | MAPTTP53CTSDCYP2A6 | |
| SCHEMBL8560277 | 0.68 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2 | |
| SCHEMBL229173 | 0.67 | CYP1A2 (0.63) | HTR3AMAPTHRH4BACE1HRH3 | |
| SCHEMBL198060 | 0.67 | BACE1 (0.50) | HTR3AHRH4BACE1HRH3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |