Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KAT7 | O95251 | 1/20 | 0.36 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559236 | 0.92 | KMT2A (0.47) | MAPTTP53ALDH1A1KMT2ATSHR | |
| SCHEMBL8554941 | 0.91 | MAPT (0.41) | MAPTALDH1A1KMT2ATSHRLIMK2 | |
| SCHEMBL8558253 | 0.91 | ALDH1A1 (0.44) | MAPTTP53ALDH1A1TSHRLIMK2 | |
| SCHEMBL8559699 | 0.88 | MAPT (0.43) | MAPTTP53ALDH1A1TSHRLIMK2 | |
| SCHEMBL8560735 | 0.87 | PTGS2 (0.43) | MAPTTP53ALDH1A1TSHRSLC40A1 | |
| SCHEMBL8556998 | 0.86 | PTPN1 (0.44) | MAPTALDH1A1KMT2ALIMK2SLC40A1 | |
| SCHEMBL9026371 | 0.86 | KMT2A (0.41) | MAPTTP53KMT2ATSHRSLC40A1 | |
| SCHEMBL8555551 | 0.86 | MAPT (0.43) | MAPTALDH1A1KMT2ATSHRLIMK2 | |
| SCHEMBL8560019 | 0.86 | MAPT (0.43) | MAPTALDH1A1KMT2ATSHRLIMK2 | |
| SCHEMBL8560574 | 0.85 | MAPT (0.46) | MAPTALDH1A1KMT2ATSHRLIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |