Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555234 | 0.93 | AURKA (0.44) | ALDH1A1AURKANR4A2HTR6MAPT | |
| SCHEMBL8557471 | 0.86 | MAPT (0.48) | ALDH1A1AURKAMAPTHSD11B1KDM4E | |
| SCHEMBL8559306 | 0.86 | RXRA (0.60) | ALDH1A1NR4A2RXRARXRBRXRG | |
| SCHEMBL8554937 | 0.85 | MAPT (0.44) | ALDH1A1AURKANR4A2MAPTHSD11B1 | |
| SCHEMBL8556747 | 0.83 | RXRA (0.59) | NR4A2RXRARXRBRXRGKDM4E | |
| SCHEMBL8557930 | 0.82 | HSD11B1 (0.44) | ALDH1A1NR4A2MAPTHSD11B1KDM4E | |
| SCHEMBL8560630 | 0.82 | MAPT (0.49) | ALDH1A1MAPTHSD11B1KDM4ENPSR1 | |
| SCHEMBL8560566 | 0.82 | NR4A2 (0.47) | ALDH1A1NR4A2RXRARXRBRXRG | |
| SCHEMBL8554882 | 0.80 | NR4A2 (0.57) | ALDH1A1NR4A2RXRARXRBRXRG | |
| SCHEMBL8555804 | 0.80 | TP53 (0.46) | ALDH1A1AURKANR4A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |