Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.59 |
| ▸ | RXRB | P28702 | 18/20 | 0.59 |
| ▸ | RXRG | P48443 | 12/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | C5 | P01031 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559306 | 0.93 | RXRA (0.60) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8560767 | 0.89 | NR4A2 (0.48) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8554882 | 0.88 | NR4A2 (0.57) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8560085 | 0.86 | KDM4E (0.51) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8554937 | 0.85 | MAPT (0.44) | NR4A2KDM4ELMNAHPGDTSHR | |
| SCHEMBL8555234 | 0.85 | AURKA (0.44) | NR4A2KDM4ELMNAHPGDTSHR | |
| SCHEMBL8557930 | 0.85 | HSD11B1 (0.44) | NR4A2KDM4ELMNAHPGDTSHR | |
| SCHEMBL8560566 | 0.84 | NR4A2 (0.47) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8559925 | 0.83 | ALDH1A1 (0.45) | RXRARXRBRXRGNR4A2KDM4E | |
| SCHEMBL8560630 | 0.82 | MAPT (0.49) | KDM4ELMNAHPGDTSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |