Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 7/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 6/20 | 0.47 |
| ▸ | RXRG | P48443 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560767 | 0.94 | NR4A2 (0.48) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8555804 | 0.91 | TP53 (0.46) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8559306 | 0.89 | RXRA (0.60) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8555950 | 0.87 | TSHR (0.44) | NR4A2RXRAHPGDTSHRMAPK1 | |
| SCHEMBL8556747 | 0.84 | RXRA (0.59) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8560085 | 0.84 | KDM4E (0.51) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8555394 | 0.83 | NR4A2 (0.47) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8559925 | 0.82 | ALDH1A1 (0.45) | NR4A2RXRARXRBRXRGHPGD | |
| SCHEMBL8554937 | 0.82 | MAPT (0.44) | NR4A2HPGDTSHRNPSR1KDM4E | |
| SCHEMBL8554882 | 0.82 | NR4A2 (0.57) | NR4A2RXRARXRBRXRGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |