Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 9/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.57 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | RXRB | P28702 | 3/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | C5 | P01031 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555950 | 0.88 | TSHR (0.44) | NR4A2NR4A1NR4A3KDM4ERXRA | |
| SCHEMBL8556747 | 0.88 | RXRA (0.59) | NR4A2NR4A1NR4A3KDM4ERXRA | |
| SCHEMBL8557930 | 0.87 | HSD11B1 (0.44) | NR4A2NR4A1NR4A3KDM4EHSD11B1 | |
| SCHEMBL8559306 | 0.85 | RXRA (0.60) | NR4A2NR4A1NR4A3KDM4ERXRA | |
| SCHEMBL8555034 | 0.85 | ALDH1A1 (0.53) | NR4A2NR4A1NR4A3KDM4ECYP2C19 | |
| SCHEMBL8560630 | 0.84 | MAPT (0.49) | KDM4EHSD11B1HPGDCYP2C19TSHR | |
| SCHEMBL8560767 | 0.83 | NR4A2 (0.48) | NR4A2NR4A1NR4A3KDM4ERXRA | |
| SCHEMBL8557471 | 0.83 | MAPT (0.48) | KDM4EHSD11B1HPGDCYP2C19TSHR | |
| SCHEMBL8554937 | 0.82 | MAPT (0.44) | NR4A2KDM4EHSD11B1HPGDCYP2C19 | |
| SCHEMBL8555234 | 0.82 | AURKA (0.44) | NR4A2KDM4EHSD11B1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |