Formamide

Formamide

SCHEMBL856006

CCOC(C)OCC.NC=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.67
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butane SCHEMBL8312214 0.95 LMNA (0.60) LMNATHRB
Formamide SCHEMBL8338621 0.93 LMNA (0.57) LMNATHRB
Acetaldehyde SCHEMBL212729 0.86 LMNA (0.71) LMNATHRB
SCHEMBL4293299 0.86 LMNA (0.71) LMNATHRB
SCHEMBL632079 0.84 LMNA (0.60) LMNATHRB
SCHEMBL8039396 0.84 LMNA (0.60) LMNATHRB
SCHEMBL3421983 0.83 LMNA (0.67) LMNATHRB
SCHEMBL10773609 0.83 LMNA (0.67) LMNATHRB
Propionaldehyde SCHEMBL1523503 0.83 LMNA (0.67) LMNATHRB
Isobutyraldehyde SCHEMBL427264 0.83 LMNA (0.67) LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110317212-B Synthesis of polycyclic carbamoylpyridone compounds 吉利德科学公司 2022-10-21 CN claimed
EP-3527573-B9 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES INC (US) 2022-07-06 EP claimed
WO-2022091001-A1 PROCESS FOR PREPARATION OF PALBOCICLIB PFIZER IRELAND PHARMACEUTICALS (IE) 2022-05-05 WO claimed
CN-114394983-A Synthesis of polycyclic carbamoylpyridone compounds 吉利德科学公司 2022-04-26 CN claimed
US-10975096-B2 Synthesis of polycyclic-carbamoylpyridone compounds GILEAD SCIENCES, INC. (US) 2021-04-13 US claimed
EP-3783001-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2021-02-24 EP claimed
EP-3527573-B1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES INC (US) 2020-08-12 EP claimed
US-20200223866-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES, INC. 2020-07-16 US claimed
CN-110317212-A The synthesis of polycyclic carbamoylpyridone compound 吉利德科学公司 2019-10-11 CN claimed
EP-3527573-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2019-08-21 EP claimed
US-5486617-A Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes LONZA LTD. (CH) 1996-01-23 US claimed
US-5401869-A Process for the preparation of aminomethylene compounds BAYER AKTIENGESELLSCHAFT (DE) 1995-03-28 US claimed
EP-0594573-A1 PREPARATION OF PROPENOIC ACID DERIVATIVES AgrEvo UK Limited (GB) 1994-05-04 EP claimed
US-5264609-A Etherification and hydrolysis SCHERING AGROCHEMICALS LIMITED (GB) 1993-11-23 US claimed
EP-0369388-B1 HYDROXY-1,2,3,4-TETRAHYDROAMINOACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-05-19 EP claimed
EP-0173190-B1 PROCESS FOR THE PREPARATION OF 5-ACYL PYRIMIDINES BAYER AG (DE) 1991-09-11 EP claimed
WO-1991007385-A1 PREPARATION OF PROPENOIC ACID DERIVATIVES SCHERING AGROCHEMICALS LIMITED (GB) 1991-05-30 WO claimed
EP-0369388-A1 Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1990-05-23 EP claimed
EP-0166697-B1 AROYL SUBSTITUTED DIHYDRO-1,4-THIAZINES CIBA-GEIGY AG (CH) 1990-05-09 EP claimed
EP-0194469-B1 SULFONE-CONTAINING STYRENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1989-01-04 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200223866-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS CPS1, SDHA, DHPS LMNA 2030/4885THRB 4294/4885
US-10975096-B2 Synthesis of polycyclic-carbamoylpyridone compounds CPS1, SDHA, DHPS LMNA 2030/4885THRB 4294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.