SCHEMBL632079

SCHEMBL632079

CCOC(C)OCC.NCC=O

nearest known ligand 0.60

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.60
THRB P10828 1/20 0.35
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionaldehyde SCHEMBL1523503 0.84 LMNA (0.67) LMNATHRBALDH1A1MAPK1TDP1
Formamide SCHEMBL856006 0.84 LMNA (0.67) LMNATHRB
SCHEMBL2917881 0.84 LMNA (0.52) LMNATHRBALDH1A1MEN1CYP1A2
SCHEMBL11485155 0.82 LMNA (0.63) LMNATHRBALDH1A1MAPK1TDP1
Malonaldehyde SCHEMBL6704192 0.82 LMNA (0.63) LMNATHRBALDH1A1MAPK1TDP1
SCHEMBL4293299 0.81 LMNA (0.71) LMNATHRBALDH1A1MAPK1TDP1
Acetaldehyde SCHEMBL212729 0.81 LMNA (0.71) LMNATHRBALDH1A1MAPK1TDP1
4-Aminobutanal SCHEMBL1437073 0.81 LMNA (0.48) LMNAALDH1A1MEN1CYP1A2KMT2A
Butane SCHEMBL8312214 0.80 LMNA (0.60) LMNATHRB
SCHEMBL8039396 0.80 LMNA (0.60) LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 414 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118530196-A Method for synthesizing 1- (2-aminoethyl) pyrrolidine by continuous hydrogenation reduction 扬州市普林斯医药科技有限公司 2024-08-23 CN claimed
CN-115541784-A Method for detecting related substances in methimazole 宁夏回族自治区药品检验研究院 2022-12-30 CN claimed
CN-109575035-B Preparation method of medicine Rucaparib intermediate for treating ovarian cancer 江苏开元药业有限公司 2021-04-16 CN claimed
US-10975096-B2 Synthesis of polycyclic-carbamoylpyridone compounds GILEAD SCIENCES, INC. (US) 2021-04-13 US claimed
EP-3783001-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2021-02-24 EP claimed
US-20200223866-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES, INC. 2020-07-16 US claimed
CN-109575035-A A kind of preparation method for treating ovarian cancer Rucaparib intermediate 江苏开元药业有限公司 2019-04-05 CN claimed
EP-2923692-B1 Beta-amino ester compounds and uses thereof LIVING PROOF INC (US) 2018-05-30 EP claimed
EP-2245132-B1 ENCAPSULATED BENEFIT AGENT UNILEVER PLC NO 41424 (GB) 2017-10-18 EP claimed
EP-3157933-A2 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2017-04-26 EP claimed
WO-2015195656-A2 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES ,INC. (US) 2015-12-23 WO claimed
CN-103396369-A Method for preparing 2-chloro-4-nitroimidazole YANCHENG INST TECHNOLOGY 2013-11-20 CN claimed
EP-1029865-B1 Process for preparing 5-lipoxygenase inhibitors PFIZER PROD INC (US) 2004-04-28 EP claimed
WO-2002020493-A2 A TRACELESS SOLID-PHASE SYNTHESIS OF 2-IMIDAZOLONES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-03-14 WO claimed
EP-0389189-B1 Diazepine antiallergy agents PFIZER LTD (GB) 1994-05-18 EP claimed
EP-0212066-B1 INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1990-11-22 EP claimed
EP-0221778-A2 Dopamine-beta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1987-05-13 EP claimed
EP-0212066-A1 Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1987-03-04 EP claimed
US-4137268-A Method of preparing aminoacetaldehyde acetals by the hydrogenation of dialkoxyacetonitrile DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1979-01-30 US claimed
CN-118530196-B Method for synthesizing 1- (2-aminoethyl) pyrrolidine by continuous hydrogenation reduction 扬州市普林斯医药科技有限公司 2026-03-24 CN disclosed
CN-119569586-A Synthesis method of aminoacetaldehyde dimethyl acetal 新沂市永诚化工有限公司 2025-03-07 CN disclosed
CN-119569586-A Synthesis method of aminoacetaldehyde dimethyl acetal 新沂市永诚化工有限公司 2025-03-07 CN disclosed
US-12202836-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2025-01-21 US disclosed
US-12091407-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2024-09-17 US disclosed
CN-118530196-A Method for synthesizing 1- (2-aminoethyl) pyrrolidine by continuous hydrogenation reduction 扬州市普林斯医药科技有限公司 2024-08-23 CN disclosed
CN-118530196-A Method for synthesizing 1- (2-aminoethyl) pyrrolidine by continuous hydrogenation reduction 扬州市普林斯医药科技有限公司 2024-08-23 CN disclosed
CN-118290334-A Preparation method of Lifeiste key intermediate 上海医药工业研究院有限公司 2024-07-05 CN disclosed
US-20230381170-A1 METHOD FOR TREATING ALS/FTD THROUGH DEGRADATION OF RNA REPEAT EXPANSION UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-11-30 US disclosed
CN-111253336-B Compounds for the treatment of cancer GTX公司 2023-11-21 CN disclosed
US-20230339960-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER (US) 2023-10-26 US disclosed
US-20230312548-A1 SUBSTITUTE FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF VTV THERAPEUTICS LLC 2023-10-05 US disclosed
CN-111542516-B IRAK4 inhibitors and uses thereof 新标立亚医疗有限公司 2023-07-18 CN disclosed
US-11702424-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2023-07-18 US disclosed
US-11649230-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2023-05-16 US disclosed
CN-115650973-A NSC69187 and synthesis method and application of derivative thereof 南方医科大学 2023-01-31 CN disclosed
CN-115541784-A Method for detecting related substances in methimazole 宁夏回族自治区药品检验研究院 2022-12-30 CN disclosed
CN-110317212-B Synthesis of polycyclic carbamoylpyridone compounds 吉利德科学公司 2022-10-21 CN disclosed
EP-3527573-B9 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES INC (US) 2022-07-06 EP disclosed
US-20220169641-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof VTVX HOLDINGS II LLC 2022-06-02 US disclosed
WO-2022086851-A1 METHOD FOR TREATING ALS/FTD THROUGH DEGRADATION OF RNA REPEAT EXPANSION THE SCRIPPS RESEARCH INSTITUTE (US) 2022-04-28 WO disclosed
CN-114394983-A Synthesis of polycyclic carbamoylpyridone compounds 吉利德科学公司 2022-04-26 CN disclosed
EP-3536685-B1 BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS PFIZER (US) 2022-02-16 EP disclosed
CN-109219609-B Fused hexacyclic imidazole derivatives as modulators of TNF activity UCB生物制药私人有限公司 2022-02-01 CN disclosed
US-11130753-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2021-09-28 US disclosed
EP-3339303-B9 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2021-07-21 EP disclosed
CN-110039069-B Spongy micron copper powder and preparation method thereof 江西省科学院能源研究所 2021-05-14 CN disclosed
CN-109575035-B Preparation method of medicine Rucaparib intermediate for treating ovarian cancer 江苏开元药业有限公司 2021-04-16 CN disclosed
CN-109575035-B Preparation method of medicine Rucaparib intermediate for treating ovarian cancer 江苏开元药业有限公司 2021-04-16 CN disclosed
US-10975096-B2 Synthesis of polycyclic-carbamoylpyridone compounds GILEAD SCIENCES, INC. (US) 2021-04-13 US disclosed
CN-112513049-A Heterocyclic compounds and their use in the prevention or treatment of bacterial infections 拜欧蒂姆公司 2021-03-16 CN disclosed
CN-106794174-B Compounds for the treatment of cancer GTX公司 2021-03-12 CN disclosed
CN-110372631-B Preparation method of aminothiazoly loximate acetaldehyde 东南大学成贤学院 2021-03-02 CN disclosed
EP-3783001-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2021-02-24 EP disclosed
US-10889580-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2021-01-12 US disclosed
US-20210002268-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof TRANSTECH PHARMA, INC. 2021-01-07 US disclosed
US-20200385370-A1 APPARATUS FOR REMOVING BAD ODOR FROM TOILET SYNBLIA THERAPEUTICS, INC. 2020-12-10 US disclosed
US-20200377511-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER INC. (US) 2020-12-03 US disclosed
CN-106458912-B Bicyclic fused heteroaryl or aryl compounds and their use as IRAK4 mimetics 辉瑞公司 2020-10-27 CN disclosed
US-10793579-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2020-10-06 US disclosed
EP-3704104-A1 IRAK4 INHIBITORS AND USES THEREOF Synblia Therapeutics, Inc. (US) 2020-09-09 EP disclosed
CN-111542516-A IRAK4 inhibitors and uses thereof 新标立亚医疗有限公司 2020-08-14 CN disclosed
EP-3527573-B1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES INC (US) 2020-08-12 EP disclosed
US-20200223866-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES, INC. 2020-07-16 US disclosed
EP-3339303-B1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2020-06-24 EP disclosed
CN-111253336-A Compounds for the treatment of cancer GTX公司 2020-06-09 CN disclosed
US-20200148673-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof VTVX HOLDINGS II LLC 2020-05-14 US disclosed
CN-108290863-B Substituted aminotriazoles useful as human chitinase inhibitors 昂科艾伦迪治疗法公司 2020-05-05 CN disclosed
US-10570126-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2020-02-25 US disclosed
CN-110709392-A Isoquinoline as HPK1 inhibitors 豪夫迈·罗氏有限公司 2020-01-17 CN disclosed
US-20190345137-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS GALAPAGOS NV (BE) 2019-11-14 US disclosed
CN-110317212-A The synthesis of polycyclic carbamoylpyridone compound 吉利德科学公司 2019-10-11 CN disclosed
EP-3536685-A1 BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS Pfizer Inc (US) 2019-09-11 EP disclosed
US-20190270751-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER INC. (US) 2019-09-05 US disclosed
EP-3527573-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2019-08-21 EP disclosed
US-20190194181-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof TRANSTECH PHARMA, INC. 2019-06-27 US disclosed
US-10329302-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2019-06-25 US disclosed
US-10287284-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2019-05-14 US disclosed
CN-106470975-B Synthesis of polycyclic carbamoylpyridone compounds 吉利德科学公司 2019-04-26 CN disclosed
CN-109575035-A A kind of preparation method for treating ovarian cancer Rucaparib intermediate 江苏开元药业有限公司 2019-04-05 CN disclosed
CN-109575035-A A kind of preparation method for treating ovarian cancer Rucaparib intermediate 江苏开元药业有限公司 2019-04-05 CN disclosed
US-10246433-B2 Aryl and heteroaryl fused lactams PFIZER INC. (US) 2019-04-02 US disclosed
US-10208020-B2 Substituted amino triazoles useful as human chitinase inhibitors Oncoarendi Therapeutics S.A. (PL) 2019-02-19 US disclosed
EP-3344616-B1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS ONCOARENDI THERAPEUTICS SA (PL) 2019-01-09 EP disclosed
US-20180291015-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof TRANSTECH PHARMA, INC. 2018-10-11 US disclosed
US-20180258071-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS GALAPAGOS NV (BE) 2018-09-13 US disclosed
US-10030011-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof VTV THERAPEUTICS LLC (US) 2018-07-24 US disclosed
EP-3344616-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS ONCOARENDI THERAPEUTICS S.A. (PL) 2018-07-11 EP disclosed
US-10011598-B2 Small molecules targeting repeat r(CGG) sequences THE SCRIPPS RESEARCH INSTITUTE (US) 2018-07-03 US disclosed
EP-3339303-A1 ARYL AND HETEROARYL FUSED LACTAMS Pfizer Inc (US) 2018-06-27 EP disclosed
US-20180127432-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER INC. (US) 2018-05-10 US disclosed
EP-2536285-B1 SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF VTV THERAPEUTICS LLC (US) 2018-04-25 EP disclosed
US-9944624-B2 Substituted amino triazoles useful as human chitinase inhibitors Oncoarendi Therapeutics S.A. (PL) 2018-04-17 US disclosed
US-9902710-B2 Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) EXONHIT THERAPEUTICS, SA (FR) 2018-02-27 US disclosed
US-9879022-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2018-01-30 US disclosed
US-20180022757-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES, INC. 2018-01-25 US disclosed
EP-2935238-B1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2017-12-27 EP disclosed
US-9809489-B2 Composition for forming a conductive film, a conductive film, a method for producing a plating film, a plating film, and an electronic device JSR CORPORATION (JP) 2017-11-07 US disclosed
WO-2017184765-A1 KAPPA OPIOID RECEPTOR COMPOUNDS AND METHODS OF USING SAME MediSynergics, LLC (US) 2017-10-26 WO disclosed
US-20170233368-A1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER INC. (US) 2017-08-17 US disclosed
US-9700563-B2 Kappa opioid receptor compounds MediSynergies, LLC (US) 2017-07-11 US disclosed
US-9675606-B2 2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors SANOFI (FR) 2017-06-13 US disclosed
US-20170152261-A1 SMALL MOLECULES TARGETING REPEAT r(CGG) SEQUENCES THE SCRIPPS RESEARCH INSTITUTE 2017-06-01 US disclosed
EP-3157933-A2 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS Gilead Sciences, Inc. (US) 2017-04-26 EP disclosed
US-20170066743-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS GALAPAGOS NV (BE) 2017-03-09 US disclosed
WO-2017037670-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS OncoArendi Therapeutics Sp. z o.o. (PL) 2017-03-09 WO disclosed
EP-2748167-B1 HEPATITIS C INHIBITOR COMPOUNDS BOEHRINGER INGELHEIM INT (DE) 2017-03-01 EP disclosed
CN-106470975-A Synthesis of Polycyclic Carbamoylpyridone Compounds 吉利德科学公司 2017-03-01 CN disclosed
EP-3126330-A1 BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS Pfizer Inc (US) 2017-02-08 EP disclosed
US-9550769-B2 Small molecules targeting repeat r(CGG) sequences THE SCRIPPS RESEARCH INSTITUTE (US) 2017-01-24 US disclosed
US-9543201-B2 Method for forming three-dimensional interconnection, circuit arrangement comprising three-dimensional interconnection, and metal film-forming composition for three-dimensional interconnection JSR CORPORATION (JP) 2017-01-10 US disclosed
US-9520574-B2 Electroluminescent devices based on phosphorescent iridium and related group VIII metal multicyclic compounds COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2016-12-13 US disclosed
US-20160347760-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER INC. (US) 2016-12-01 US disclosed
US-9475788-B2 Antiprotozoal compounds MediSynergics, LLC (US) 2016-10-25 US disclosed
US-9458168-B2 Bicyclic-fused heteroaryl or aryl compounds PFIZER INC. (US) 2016-10-04 US disclosed
US-20160264549-A1 SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A) EXONHIT THERAPEUTICS, SA (FR) 2016-09-15 US disclosed
US-20160235759-A1 Kappa Opioid Receptor Compounds MediSynergics, LLC (US) 2016-08-18 US disclosed
US-9346777-B2 Antiprotozoal compounds MediSynergics, LLC (US) 2016-05-24 US disclosed
US-9340548-B2 Substituted pyrazolo[3,4-a]carbazoles as hepatitis C inhibitors Boehringer Ingehleim International GmbH (DE) 2016-05-17 US disclosed
CN-103396369-B A kind of method preparing the chloro-4-nitroimidazole of 2- YANGCHENG INSTITUTE OF TECHNOLOGY (CN) 2016-03-23 CN disclosed
CN-103396369-B A kind of method preparing the chloro-4-nitroimidazole of 2- YANGCHENG INSTITUTE OF TECHNOLOGY (CN) 2016-03-23 CN disclosed
US-20160081189-A1 COMPOSITION FOR FORMING A CONDUCTIVE FILM, A CONDUCTIVE FILM, A METHOD FOR PRODUCING A PLATING FILM, A PLATING FILM, AND AN ELECTRONIC DEVICE JSR CORPORATION (JP) 2016-03-17 US disclosed
US-9284291-B2 Kappa opioid receptor compounds MediSynergies, LLC (US) 2016-03-15 US disclosed
US-20160064280-A1 METHOD FOR FORMING THREE-DIMENSIONAL INTERCONNECTION, CIRCUIT ARRANGEMENT COMPRISING THREE-DIMENSIONAL INTERCONNECTION, AND METAL FILM-FORMING COMPOSITION FOR THREE-DIMENSIONAL INTERCONNECTION JSR CORPORATION (JP) 2016-03-03 US disclosed
US-20160057866-A1 METAL FILM FORMING METHOD AND CONDUCTIVE INK USED IN SAID METHOD JSR CORPORATION (JP) 2016-02-25 US disclosed
US-20160039799-A1 Antiprotozoal Compounds MediSynergics, LLC (US) 2016-02-11 US disclosed
US-20160031844-A1 Kappa Opioid Receptor Compounds GODEK DENNIS MICHAEL (US) 2016-02-04 US disclosed
US-20150368264-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES, INC. 2015-12-24 US disclosed
WO-2015195656-A2 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS GILEAD SCIENCES ,INC. (US) 2015-12-23 WO disclosed
US-9200016-B2 Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) ALLERGAN, INC. (US) 2015-12-01 US disclosed
US-20150328205-A1 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS SANOFI (FR) 2015-11-19 US disclosed
US-20150307487-A1 SMALL MOLECULES TARGETING REPEAT r(CGG) SEQUENCES UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2015-10-29 US disclosed
EP-2935238-A1 ARYL AND HETEROARYL FUSED LACTAMS Pfizer Inc. (US) 2015-10-28 EP disclosed
US-20150291592-A1 HEPATITIS C INHIBITOR COMPOUNDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-10-15 US disclosed
WO-2015150995-A1 BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS PFIZER INC. (US) 2015-10-08 WO disclosed
US-20150284405-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds PFIZER INC. (US) 2015-10-08 US disclosed
EP-2628741-B1 NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR JW PHARMACEUTICAL CORP (KR) 2015-10-07 EP disclosed
US-9126972-B2 2-amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors SANOFI (FR) 2015-09-08 US disclosed
CN-104870446-A Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors NERVIANO MEDICAL SCIENCES SRL 2015-08-26 CN disclosed
US-20150175572-A1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER INC. (US) 2015-06-25 US disclosed
EP-2709996-B1 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS SANOFI SA (FR) 2015-06-24 EP disclosed
WO-2015084731-A1 ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2015-06-11 WO disclosed
US-20150158895-A1 SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A) ALLERGAN, INC. (US) 2015-06-11 US disclosed
US-9040515-B2 Aryl and heteroaryl fused lactams PFIZER INC. (US) 2015-05-26 US disclosed
US-20150038507-A1 Antiprotozoal Compounds GODEK DENNIS MICHAEL (US) 2015-02-05 US disclosed
US-8940739-B2 Compound of a reverse-turn mimetic and a production method and use therefor JW PHARMACEUTICAL CORPORATION (KR) 2015-01-27 US disclosed
EP-1841504-B1 SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-11-19 EP disclosed
US-20140194349-A1 HIV Protease Inhibiting Compounds ABBVIE INC. (US) 2014-07-10 US disclosed
EP-2748167-A1 HEPATITIS C INHIBITOR COMPOUNDS Boehringer Ingelheim International GmbH (DE) 2014-07-02 EP disclosed
US-20140179667-A1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER INC. (US) 2014-06-26 US disclosed
WO-2014097041-A1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER INC. (US) 2014-06-26 WO disclosed
US-8759535-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof HIGH POINT PHARMACEUTICALS, LLC (US) 2014-06-24 US disclosed
EP-2709996-A1 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS SANOFI (FR) 2014-03-26 EP disclosed
WO-2014036395-A1 SMALL MOLECULES TARGETING REPEAT r(CGG) SEQUENCES THE SCRIPPS RESEARCH INSTITUTE (US) 2014-03-06 WO disclosed
US-8653141-B2 HIV protease inhibiting compounds ABBVIE INC. (US) 2014-02-18 US disclosed
CN-103396369-A Method for preparing 2-chloro-4-nitroimidazole YANCHENG INST TECHNOLOGY 2013-11-20 CN disclosed
CN-103396369-A Method for preparing 2-chloro-4-nitroimidazole YANCHENG INST TECHNOLOGY 2013-11-20 CN disclosed
CN-101616909-B Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase SANOFI AVENTIS SPA 2013-09-11 CN disclosed
EP-2628741-A2 NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR JW Pharmaceutical Corporation (KR) 2013-08-21 EP disclosed
EP-2264032-B1 HIV PROTEASE INHIBITING SULFONAMIDES ABBVIE INC (US) 2013-08-07 EP disclosed
US-20130196972-A1 NOVEL COMPOUND OF A REVERSE-TURN MIMETIC AND A PRODUCTION METHOD AND USE THEREFOR JW PHARMACEUTICAL CORPORATION (KR) 2013-08-01 US disclosed
US-20130131018-A1 SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS EXONHIT S.A. (FR) 2013-05-23 US disclosed
EP-2576514-A1 SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS EXONHIT SA (FR) 2013-04-10 EP disclosed
US-20130082248-A1 ELECTROLUMINESCENT DEVICES BASED ON PHOSPHORESCENT IRIDIUM AND RELATED GROUP VIII METAL MULTICYCLIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2013-04-04 US disclosed
CN-102971316-A Fused bicyclic kinase inhibitors OSI PHARMACEUTICALS LLC 2013-03-13 CN disclosed
EP-1966164-B1 NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES JANSSEN PHARMACEUTICA NV (BE) 2013-03-06 EP disclosed
EP-2564446-A1 ELECTROLUMINESCENT DEVICES BASED ON PHOSPHORESCENT IRIDIUM AND RELATED GROUP VIII METAL MULTICYCLIC COMPOUNDS Commonwealth Scientific and Industrial Research Organisation (AU) 2013-03-06 EP disclosed
WO-2013026162-A1 HEPATITIS C INHIBITOR COMPOUNDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-02-28 WO disclosed
US-20130023463-A1 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2013-01-24 US disclosed
EP-2536285-A1 SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF High Point Pharmaceuticals, LLC (US) 2012-12-26 EP disclosed
US-8329704-B2 Substituted pyrazinone derivatives for use in MCH-1 mediated diseases JANSSEN PHARMACEUTICA, N.V. (BE) 2012-12-11 US disclosed
WO-2012159959-A1 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS SANOFI (FR) 2012-11-29 WO disclosed
EP-2524915-A1 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors SANOFI (FR) 2012-11-21 EP disclosed
US-8309721-B2 HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof SANOFI (FR) 2012-11-13 US disclosed
EP-2216334-B1 HIV protease inhibiting sulfonamides ABBOTT LAB (US) 2012-10-31 EP disclosed
US-8217031-B2 Heteroaryl derivatives NIPPON SHINYAKU CO., LTD. (JP) 2012-07-10 US disclosed
US-8193227-B2 HIV protease inhibiting compounds ABBOTT LABORATORIES (US) 2012-06-05 US disclosed
US-8178687-B2 Derivatives of pyrroloindole which are inhibitors of Hsp90, compositions containing same, and use thereof SANOFI-AVENTIS (FR) 2012-05-15 US disclosed
EP-2419430-A2 NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF JW Pharmaceutical Corporation (KR) 2012-02-22 EP disclosed
EP-1697348-B1 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LAB (US) 2011-12-28 EP disclosed
WO-2011151423-A1 SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS EXONHIT S.A. (FR) 2011-12-08 WO disclosed
US-8063078-B2 Urea-compounds active as vanilloid receptor antagonists for the treatment of pain GLAXOSMITHKLINE LLC (US) 2011-11-22 US disclosed
WO-2011134013-A1 ELECTROLUMINESCENT DEVICES BASED ON PHOSPHORESCENT IRIDIUM AND RELATED GROUP VIII METAL MULTICYCLIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2011-11-03 WO disclosed
EP-1697344-B1 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LAB (US) 2011-09-28 EP disclosed
WO-2011103018-A1 SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF HIGH POINT PHARMACEUTICALS, LLC (US) 2011-08-25 WO disclosed
US-20110201604-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof HIGH POINT PHARMACEUTICALS, LLC (US) 2011-08-18 US disclosed
US-20110184015-A1 NOVEL DERIVATIVES OF PYRROLOINDOLE WHICH ARE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF SANOFI-AVENTIS (FR) 2011-07-28 US disclosed
US-20110166169-A1 NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF SANOFI-AVENTIS (FR) 2011-07-07 US disclosed
EP-2298757-A2 Urea compounds active as vanilloid receptor antagonist for the treatment of pain Glaxo Group Limited (GB) 2011-03-23 EP disclosed
EP-1641795-B1 TRIAZA- AND TETRAAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS SANOFI AVENTIS DEUTSCHLAND (DE) 2011-03-09 EP disclosed
US-20110053932-A1 Protein Kinase Inhibitors and Methods for Using Thereof IRM LLC 2011-03-03 US disclosed
US-20110003827-A1 HIV protease inhibiting compounds ABBVIE INC. 2011-01-06 US disclosed
EP-2266971-A2 Hiv protease inhibiting compounds Abbott Laboratories (US) 2010-12-29 EP disclosed
EP-2264032-A2 Hiv protease inhibiting sulfonamides Abbott Laboratories (US) 2010-12-22 EP disclosed
US-7834043-B2 Prevent reproduct of aids virus ABBOTT LABORATORIES (US) 2010-11-16 US disclosed
US-20100267672-A1 NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF CHOONGWAE PHARMA CORPORATION (KR) 2010-10-21 US disclosed
WO-2010120112-A2 NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF CHOONGWAE PHARMA CORPORATION (KR) 2010-10-21 WO disclosed
US-20100249181-A1 HIV Protease Inhibiting Compounds ABBOTT LABORATORIES (US) 2010-09-30 US disclosed
EP-1349005-B1 Photosensitive compound, resin and composition TOYO GOSEI CO LTD (JP) 2010-09-01 EP disclosed
EP-2216334-A1 Hiv protease inhibiting sulfonamides Abbott Laboratories (US) 2010-08-11 EP disclosed
US-7696226-B2 HIV protease inhibiting compounds ABBOTT LABORATORIES (US) 2010-04-13 US disclosed
EP-2170842-A1 PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF IRM, LLC (BM) 2010-04-07 EP disclosed
US-20100048537-A1 HETEROARYL DERIVATIVES NIPPON SHINYAKU CO., LTD. (JP) 2010-02-25 US disclosed
US-7645799-B2 Substituted biaryl compounds as factor XIa inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2010-01-12 US disclosed
EP-2141168-A1 HETEROARYL DERIVATIVES Nippon Shinyaku Co., Ltd. (JP) 2010-01-06 EP disclosed
CN-101616909-A Substituted isoquinoline 99.9 and isoquinolinone derivatives as the Rho-kinase inhibitor SANOFI AVENTIS 2009-12-30 CN disclosed
EP-1709037-B1 HIV PROTEASE INHIBITING SULFONAMIDES ABBOTT LAB (US) 2009-12-23 EP disclosed
US-20090305983-A1 Curable Bone Cement AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2009-12-10 US disclosed
CN-101573353-A Substituted isoquinoline and isoquinolinone derivatives SANOFI AVENTIS (FR) 2009-11-04 CN disclosed
US-7592401-B2 Multinuclear half metallocene catalyst and method for preparing syndiotatic polystyrene using the same LG CHEM, LTD. (KR) 2009-09-22 US disclosed
US-20090169532-A1 CURABLE BONE CEMENT AGENCY OF SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2009-07-02 US disclosed
US-20090163506-A1 Urea-compounds active as vanilloid receptor antagonists for the treatment of pain SMITHKLINE BEECHAM PLC. (GB) 2009-06-25 US disclosed
US-20090137597-A1 Novel quinoxalinone derivatives MSD K.K. (JP) 2009-05-28 US disclosed
EP-1425277-B8 UREA-COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN GLAXO GROUP LTD (GB) 2009-04-01 EP disclosed
EP-2036902-A2 Urea compounds active as vanilloid receptor antagonist for the treatment of pain Glaxo Group Limited (GB) 2009-03-18 EP disclosed
US-20090062287-A1 SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2009-03-05 US disclosed
US-20090012062-A1 Novel Substituted Pyrazinone Derivatives for Use in Mch-1 Mediated Diseases BIOFOCUS DISCOVERY LTD. (GB) 2009-01-08 US disclosed
WO-2008157575-A1 PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF IRM LLC (BM) 2008-12-24 WO disclosed
CN-100441188-C Benzazepine * derivatives as MAO-B inhibitors HOFFMANN LA ROCHE (CH) 2008-12-10 CN disclosed
US-7459564-B2 Substituted biaryl compounds as factor XIa inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-12-02 US disclosed
EP-1363993-A4 METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF I$g(k)B KINASE (IKK) BRISTOL MYERS SQUIBB CO (US) 2008-11-12 EP disclosed
EP-1988938-A1 CURABLE BONE CEMENT Agency for Science, Technology and Research (SG) 2008-11-12 EP disclosed
EP-1680127-B1 BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS HOFFMANN LA ROCHE (CH) 2008-10-15 EP disclosed
EP-1966164-A1 NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES Janssen Pharmaceutica, N.V. (BE) 2008-09-10 EP disclosed
US-7420035-B2 Purification of polypeptides Atheris Laboratories, Dr. Reto Stocklin et Sylvie Stocklin Associes (CH) 2008-09-02 US disclosed
US-20080194872-A1 PURIFICATION OF POLYPEPTIDES UNIVERSITE DE GENEVE (CH) 2008-08-14 US disclosed
CN-101228132-A Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors SANOFI AVENTIS (FR) 2008-07-23 CN disclosed
CN-101228149-A Piperidinyl-substituted isoquinolinone derivatives as Rho-kinase inhibitors SANOFI AVENTIS (FR) 2008-07-23 CN disclosed
US-7388010-B2 Quinoxalinone derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2008-06-17 US disclosed
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases METABASIS THERAPEUTICS, INC. (US) 2008-03-20 US disclosed
EP-1828123-A1 INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS Boehringer Ingelheim International GmbH (DE) 2007-09-05 EP disclosed
WO-2007097710-A1 CURABLE BONE CEMENT AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2007-08-30 WO disclosed
WO-2007071646-A1 NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES JANSSEN PHARMACEUTICA N.V. (BE) 2007-06-28 WO disclosed
US-20070117791-A1 Bicyclic compounds JOLIDON SYNESE 2007-05-24 US disclosed
US-20070100095-A1 Multinuclear half metallocene catalyst and method for preparing syndiotatic polystyren using the same LG CHEM, LTD. (KR) 2007-05-03 US disclosed
EP-1777230-A1 Multinuclear half metallocene catalyst and method for preparing syndiotactic polystyrene using the same LG Chem Ltd. (KR) 2007-04-25 EP disclosed
US-20070088051-A1 INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-04-19 US disclosed
US-20070072096-A1 Negative curable dye-containing composition, color filter, and method of manufacturing the same FUJI PHOTO FILM CO., LTD. 2007-03-29 US disclosed
US-7173023-B2 Bicyclic compounds HOFFMANN-LA ROCHE INC. (US) 2007-02-06 US disclosed
CN-1871013-A Benzazepine derivatives as MAO-B inhibitors HOFFMANN LA ROCHE (CH) 2006-11-29 CN disclosed
US-7132536-B2 Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2006-11-07 US disclosed
EP-1709037-A2 HIV PROTEASE INHIBITING SULFONAMIDES ABBOTT LABORATORIES (US) 2006-10-11 EP disclosed
EP-1697348-A1 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2006-09-06 EP disclosed
EP-1697344-A2 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2006-09-06 EP disclosed
WO-2006078698-A1 2-IMIDAZOLONE AND 2-IMIDAZOLIDINONE HETEROCYCLIC INHIBITORS OF TYROSINE PHOSPHATASES CENGENT THERAPEUTICS, INC. (US) 2006-07-27 WO disclosed
EP-1680127-A1 BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-07-19 EP disclosed
US-20060154915-A1 Substituted biaryl compounds as factor XIa inhibitors BRISTOL-MYERS SQUIBB COMPANY 2006-07-13 US disclosed
WO-2006064044-A1 INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-06-22 WO disclosed
US-20060135592-A1 Indolinones and their use as antiproliferative agents BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-06-22 US disclosed
EP-1641795-A1 TRIAZA- AND TETRAAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Sanofi-Aventis Deutschland GmbH (DE) 2006-04-05 EP disclosed
EP-1325009-B1 AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME BRISTOL MYERS SQUIBB CO (US) 2006-03-08 EP disclosed
US-20060019959-A1 Novel quinoxalinone derivatives BANYU PHARMACEUTICAL CO., LTD. TSUKUBA RESEARCH INSTITUTE (JP) 2006-01-26 US disclosed
US-6960585-B2 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY (US) 2005-11-01 US disclosed
EP-1557418-A1 NOVEL QUINOXALINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 2005-07-27 EP disclosed
US-20050159469-A1 HIV protease inhibiting compounds ABBVIE INC. 2005-07-21 US disclosed
WO-2005061450-A2 HIV PROTEASE INHIBITING SULFONAMIDES ABBOTT LABORATORIES (US) 2005-07-07 WO disclosed
WO-2005061487-A1 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2005-07-07 WO disclosed
US-20050148623-A1 Prevent reproduct of aids virus ABBVIE INC. 2005-07-07 US disclosed
WO-2005058841-A2 HIV PROTEASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 2005-06-30 WO disclosed
US-20050131042-A1 HIV protease inhibiting compounds ABBOTT LABORATORIES 2005-06-16 US disclosed
US-20050131017-A1 HIV protease inhibiting compounds ABBOTT LABORATORIES 2005-06-16 US disclosed
US-20050107360-A1 Bicyclic compounds HOFFMANN-LA ROCHE INC. 2005-05-19 US disclosed
WO-2005039591-A1 BENZAZEPINE DERIVATIVES AS MAO-B INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-05-06 WO disclosed
US-6869956-B2 Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) BRISTOL-MYERS SQUIBB COMPANY (US) 2005-03-22 US disclosed
US-6861456-B2 Photosensitive compound, photosensitive resin, and photosensitive composition TOYO GOSEI KOGYO CO., LTD. (JP) 2005-03-01 US disclosed
US-20050025740-A1 Polyoxime compounds and their preparation AMYLIN PHARMACEUTICALS, INC. 2005-02-03 US disclosed
US-20040266901-A1 NOVEL PHOTOSENSITIVE COMPOUND, PHOTOSENSITIVE RESIN, AND PHOTOSENSITIVE COMPOSITION TOYO GOSEI KOGYO CO., LTD. (JP) 2004-12-30 US disclosed
US-20040248900-A1 Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-12-09 US disclosed
WO-2004094425-A1 Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2004-11-04 WO disclosed
EP-1471066-A1 Triaza- and tetraaza-anthracenedione derivates, their preparation and their use as pharmaceuticals Aventis Pharma Deutschland GmbH (DE) 2004-10-27 EP disclosed
EP-1425277-A2 UREA-COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN SmithKline Beecham P.L.C. (GB) 2004-06-09 EP disclosed
JP-2004143056-A METHOD FOR PRODUCING 2-MERCAPTOIMIDAZOLES NIPPON SYNTHETIC CHEM IND CO LTD:THE 2004-05-20 JP disclosed
US-6709679-B2 CONSISTING OF NATIVE OR THIOLATED TRANSFERRIN OR ALBUMIN OR OF POLYETHYLENE GLYCOL WITH ATLEAST ONE MERCAPTAN, HYDROXY OR AMINE GROUP AND CYTOSTATIC COMPOUNDS DERIVED THROUGH MALEINIMIDE OR HYDROXYSUCCINIMIDE ESTER COMPOUNDS KRATZ FELIX (DE) 2004-03-23 US disclosed
US-6663869-B1 Linkages between polypeptide organic molecules are oxime linkages formed by reaction of a keto, aldehyde or amino-oxy group on the amino acid GRYPHON THERAPEUTICS, INC. 2003-12-16 US disclosed
EP-1363993-A2 METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF I$g(k)B KINASE (IKK) Bristol-Myers Squibb Company (US) 2003-11-26 EP disclosed
EP-1349005-A1 Photosensitive compound, resin and composition Toyo Gosei Kogyo Co., Ltd. (JP) 2003-10-01 EP disclosed
US-20030135031-A1 Purification of polypeptides ATHERIS LABORATORIES, DR RETO STOCKLIN (CH) 2003-07-17 US disclosed
EP-1325009-A2 AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME Bristol-Myers Squibb Company (US) 2003-07-09 EP disclosed
EP-1137798-A4 A METHOD OF ISOLATING STEM CELLS UNIV DUKE (US) 2003-06-25 EP disclosed
WO-2003022809-A2 UREA-COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN SMITHKLINE BEECHAM P.L.C. (GB) 2003-03-20 WO disclosed
US-20030022898-A1 Methods of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK) BRISTOL-MYERS SQUIBB COMPANY 2003-01-30 US disclosed
EP-1274722-A2 PURIFICATION OF POLYPEPTIDES UNIVERSITE DE GENEVE (CH) 2003-01-15 EP disclosed
US-6479436-B1 SUCH AS 2-(8-BROMOQUINOLIN-5-YL)CARBONYL-1,3-CYCLOHEXANEDIONE BASF AKTIENGESELLSCHAFT (DE) 2002-11-12 US disclosed
WO-2002020493-A3 A TRACELESS SOLID-PHASE SYNTHESIS OF 2-IMIDAZOLONES CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-10-31 WO disclosed
WO-2002060386-A2 METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF IλB KINASE (IKK) BRISTOL-MYERS SQUIBB COMPANY (US) 2002-08-08 WO disclosed
US-20020072523-A1 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY 2002-06-13 US disclosed
WO-2002028860-A2 AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME BRISTOL-MYERS SQUIBB COMPANY (US) 2002-04-11 WO disclosed
WO-2002020493-A2 A TRACELESS SOLID-PHASE SYNTHESIS OF 2-IMIDAZOLONES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-03-14 WO disclosed
WO-2002020493-A2 A TRACELESS SOLID-PHASE SYNTHESIS OF 2-IMIDAZOLONES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-03-14 WO disclosed
US-20020019343-A1 Antineoplastic conjugates of transferrin, albumin and polyethylene glycol KRATZ FELIX (DE) 2002-02-14 US disclosed
WO-2001081367-A2 PURIFICATION OF POLYPEPTIDES UNIVERSITE DE GENEVE (CH) 2001-11-01 WO disclosed
US-6310039-B1 TUMOR-INHIBITING CONJUGATES OF PROTEINS AND POLYMERS CONSISTING OF A SUITABLE CARRIER SYSTEM AND CYTOSTATIC COMPOUNDS KRATZ FELIX (DE) 2001-10-30 US disclosed
EP-1137798-A1 A METHOD OF ISOLATING STEM CELLS DUKE UNIVERSITY (US) 2001-10-04 EP disclosed
EP-0741709-B1 AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS ALLERGAN SALES INC (US) 2001-07-25 EP disclosed
US-6262074-B1 4-Hetaroylpyrazol derivatives and the use thereof as herbicides BASF AKTIENGESELLSCHAFT (DE) 2001-07-17 US disclosed
US-6217873-B1 HOMOGENEOUS; MEDICAL DIAGNOSIS GRYPHON SCIENCES 2001-04-17 US disclosed
US-6174530-B1 Homogeneous polyoxime compositions and their preparation by parallel assembly GRYPHON SCIENCES 2001-01-16 US disclosed
US-6114390-A AN ARGININAMIDE OR ORNITHINAMIDE COMPOUND AS TREATING MEMORY LOSS, MIGRAINE, SLEEP DISORDERS, PAIN, CARDIOVASCULAR DISEASES, SUBARACHNOIDAL BLEEDING, VASCULAR-HYPERTROPHIC CHANGES, CEREBRAL AND CORONARY VASOSPASMS KARL THOMAE GMBH (DE) 2000-09-05 US disclosed
WO-2000034507-A1 A METHOD OF ISOLATING STEM CELLS DUKE UNIVERSITY (US) 2000-06-15 WO disclosed
EP-0697891-B1 POLYOXIME COMPOUNDS AND THEIR PREPARATION ROSE KEITH (CH) 2000-03-29 EP disclosed
US-6001364-A COMPRISING A BASEPLATE STRUCTURE HAVING A PLURALITY OF OXIME BONDS, WHEREIN EACH OXIME BOND LINKS A SPECIFICALLY ACTIVE MOLECULE TO THE BASEPLATE; FOR INDUCING AN IMMUNE RESPONSE IN AN ANIMAL GRYPHON SCIENCES (US) 1999-12-14 US disclosed
CN-1235600-A 4-hetaroylpyrazol derivatives BASF AG (DE) 1999-11-17 CN disclosed
CN-1230951-A Herbicidal heteroaroyl cyclohexanedione derivatives BASF AG (DE) 1999-10-06 CN disclosed
WO-1999007750-A1 PERFLUORINATED RESINS AS A SUPPORT FOR SOLID PHASE REACTIONS THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) 1999-02-18 WO disclosed
EP-0885186-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-12-23 EP disclosed
WO-1998046593-A1 NOVEL CARBOSTYRIL DERIVATIVE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-10-22 WO disclosed
EP-0500045-B1 Process of processing silver halide photographic material and photographic processing composition having a fixing ability FUJI PHOTO FILM CO LTD (JP) 1998-05-13 EP disclosed
WO-1997019911-A1 AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM DR. KARL THOMAE GMBH (DE) 1997-06-05 WO disclosed
EP-0741709-A1 AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS Allergan (US) 1996-11-13 EP disclosed
US-5532233-A PLATELET ACTIVATING FACTOR ANTAGONIST BOEHRINGER INGELHEIM KG (DE) 1996-07-02 US disclosed
US-5521177-A ANGIOTENSIN ANTAGONIST FOR CARDIOVASCULAR DISORDERS SUCH AS ISCHEMIA OR CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS COGNITIVE FUNCTIONS, DEPRESSION, ALZHEIMER'S DISEASE OR PARKINSON'S SYNDROME DR. KARL THOMAE GMBH (DE) 1996-05-28 US disclosed
US-5514694-A ENZYME INHIBITORS GEORGIA TECH RESEARCH CORP (US) 1996-05-07 US disclosed
EP-0697891-A1 POLYOXIME COMPOUNDS AND THEIR PREPARATION Rose, Keith (CH) 1996-02-28 EP disclosed
WO-1995019968-A1 AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS ALLERGAN (US) 1995-07-27 WO disclosed
EP-0650368-A1 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1995-05-03 EP disclosed
EP-0249239-B1 Process for the formation of direct positive images FUJI PHOTO FILM CO LTD (JP) 1995-01-25 EP disclosed
EP-0249938-B1 Imidazolesulfonamide derivatives, herbicides and a method for inhibiting growth of undesirable plants NISSAN CHEMICAL IND LTD (JP) 1994-12-14 EP disclosed
WO-1994025071-A1 POLYOXIME COMPOUNDS AND THEIR PREPARATION ROSE KEITH (CH) 1994-11-10 WO disclosed
EP-0244803-B1 Novel dopamine beta hydroxylase inhibitors MERRELL DOW PHARMA (US) 1994-10-26 EP disclosed
US-5338648-A Process of processing silver halide photographic material and photographic processing composition having a fixing ability FUJI PHOTO FILM CO., LTD. (JP) 1994-08-16 US disclosed
CN-1088202-A Benzoglyoxaline contains pharmaceutical composition of these compounds and preparation method thereof THOMAE GMBH DR K (DE) 1994-06-22 CN disclosed
EP-0389189-B1 Diazepine antiallergy agents PFIZER LTD (GB) 1994-05-18 EP disclosed
WO-1994000095-A2 USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY CORTEX PHARMACEUTICALS, INC. (US) 1994-01-06 WO disclosed
US-5162534-A Process for the preparation of thiazoline derivatives KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1992-11-10 US disclosed
EP-0283041-B1 DIRECT POSITIVE SILVER HALIDE PHOTOSENSITIVE MATERIAL AND METHOD FOR FORMING DIRECT POSITIVE IMAGE FUJI PHOTO FILM CO., LTD. (JP) 1992-10-07 EP disclosed
EP-0500045-A1 Process of processing silver halide photographic material and photographic processing composition having a fixing ability FUJI PHOTO FILM CO., LTD. (JP) 1992-08-26 EP disclosed
EP-0260814-B1 DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1992-02-05 EP disclosed
EP-0238060-B1 CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS Banyu Pharmaceutical Co., Ltd. (JP) 1992-01-08 EP disclosed
EP-0166937-B1 ADRENERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1991-08-28 EP disclosed
US-5008263-A Platelet activating factor antagonists; antiallergens; antiinflammatory agents PFIZER INC. (US) 1991-04-16 US disclosed
US-4992459-A Hypotensive agents, antiulcer agents SMITHKLINE BEECHAM CORPORATION (US) 1991-02-12 US disclosed
EP-0404694-A2 4-hydroxy-8-methoxy-2-methyl-6, 7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline, and process for preparing the same MITSUBISHI KASEI CORPORATION (JP) 1990-12-27 EP disclosed
EP-0212066-B1 INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1990-11-22 EP disclosed
US-4963684-A OXIDATION AMINO GROUP OF A TETRAHYDROISOQUINOLINE COMPOUND; HYDROLYSIS MITSUBISHI KASEI CORPORATION (JP) 1990-10-16 US disclosed
CN-1045783-A Diaza  class anti-allergy medicament PFIZER (US) 1990-10-03 CN disclosed
EP-0389189-A2 Diazepine antiallergy agents Pfizer Limited (GB) 1990-09-26 EP disclosed
EP-0387156-A2 A process for preparing cotarnine MITSUBISHI KASEI CORPORATION (JP) 1990-09-12 EP disclosed
EP-0288488-A4 DOPAMINE- -HYDROXYLASE INHIBITORS 1990-09-12 EP disclosed
US-4954427-A Development of light-sensitive material in the presence of a nucleating agent and a nuceation accelerator FUJI PHOTO FILM CO., LTD. (JP) 1990-09-04 US disclosed
US-4952483-A NOVEL HYDRAZINE NUCLEATING AGENTS AND ACCELERATORS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-28 US disclosed
US-4933265-A NUCLEATION PROMOTER FUJI PHOTO FILM CO., LTD. (JP) 1990-06-12 US disclosed
EP-0140640-B1 BLOOD SUBSTITUTE FISONS plc (GB) 1990-04-04 EP disclosed
US-4873357-A Trifluoro acetyl-cyano-aniline intermediates for dopamine-βhydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1989-10-10 US disclosed
US-4863944-A Dopamine-β-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1989-09-05 US disclosed
US-4839365-A Thienopyridine derivatives useful in treating gastric ulcers SHINOGI & CO., LTD. (JP) 1989-06-13 US disclosed
US-4830660-A Imidazolesulfonamide derivatives and herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1989-05-16 US disclosed
EP-0125033-B1 DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1989-04-26 EP disclosed
EP-0308573-A2 Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1989-03-29 EP disclosed
US-4814328-A Cephalosporin derivatives, and antibacterial agents BANYU PHARMACEUTICAL CO., LTD. (JP) 1989-03-21 US disclosed
US-4810800-A HYPOTENSIVE AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1989-03-07 US disclosed
EP-0125783-B1 DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1989-01-04 EP disclosed
EP-0292051-A2 Thienopyridine derivatives SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1988-11-23 EP disclosed
US-4785010-A AGING RESISTANCE OF HUMANS CASSELLA AKTIENGESELLSCHAFT (DE) 1988-11-15 US disclosed
EP-0288488-A1 DOPAMINE- -HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1988-11-02 EP disclosed
US-4782155-A ISOQUINOLINE SALTS BANYU PHARMACEUTICAL CO., LTD. (JP) 1988-11-01 US disclosed
EP-0283041-A1 Direct positive silver halide photosensitive material and method for forming direct positive image FUJI PHOTO FILM CO., LTD. (JP) 1988-09-21 EP disclosed
US-4772723-A Dopamine β-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1988-09-20 US disclosed
US-4769480-A Benzylamine derivative MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1988-09-06 US disclosed
US-4761480-A DOPAMINE-BETA-HYDROXYLASE INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1988-08-02 US disclosed
US-4760145-A Certain 6,7-methylene dioxydihydro or tetrahydro-isoquinoline derivatives MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1988-07-26 US disclosed
US-4743613-A Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity SMITHKLINE BECKMAN CORPORATION (US) 1988-05-10 US disclosed
EP-0260814-A1 Dopamine-Beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1988-03-23 EP disclosed
WO-1988001267-A1 DOPAMINE-ss-HYDROXYLASE INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1988-02-25 WO disclosed
US-4719223-A ENZYME INHIBITORS, HYPOTENSIVE, CARDIOTONIC DIURETIC SMITHKLINE BECKMAN CORPORATION (US) 1988-01-12 US disclosed
EP-0249938-A2 Imidazolesulfonamide derivatives, herbicides and a method for inhibiting growth of undesirable plants NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1987-12-23 EP disclosed
EP-0249239-A2 Process for the formation of direct positive images FUJI PHOTO FILM CO., LTD. (JP) 1987-12-16 EP disclosed
US-4710488-A SYNTHETIC BLOOD; LOW OXYGEN AFFINITY FISONS PLC (GB) 1987-12-01 US disclosed
EP-0244803-A2 Novel dopamine beta hydroxylase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1987-11-11 EP disclosed
EP-0244956-A1 Ester prodrugs of dopamine-beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1987-11-11 EP disclosed
US-4701556-A 7-(IMIDAZOL-2-YL-AMINO) CEPHEMS AND OXACEPHEMS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-20 US disclosed
EP-0238060-A2 Cephalosporin derivatives, processes for their preparation and antibacterial agents Banyu Pharmaceutical Co., Ltd. (JP) 1987-09-23 EP disclosed
EP-0221778-A2 Dopamine-beta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1987-05-13 EP disclosed
EP-0216696-A2 Process for preparing cotarnine MITSUBISHI KASEI CORPORATION (JP) 1987-04-01 EP disclosed
EP-0214740-A2 Dopamine-beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1987-03-18 EP disclosed
EP-0214905-A2 Tetrahydroisoquinoline derivatives MITSUBISHI KASEI CORPORATION (JP) 1987-03-18 EP disclosed
US-4650786-A OXYGENATION OF TISSUES FISONS PLC (GB) 1987-03-17 US disclosed
EP-0214051-A2 Benzylamine derivative MITSUBISHI KASEI CORPORATION (JP) 1987-03-11 EP disclosed
EP-0212066-A1 Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 1987-03-04 EP disclosed
US-4634705-A Adrenergic amidines ABBOTT LABORATORIES (US) 1987-01-06 US disclosed
US-4634711-A ENZYME INHIBITORS SMITHKLINE BECKMAN CORPORATION (US) 1987-01-06 US disclosed
US-4610954-A ANTIFOGGING AGENTS FUJI PHOTO FILM CO., LTD. (JP) 1986-09-09 US disclosed
US-4584384-A HISTAMINE H2-ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1986-04-22 US disclosed
EP-0115400-B1 TRIAZOLE ANTIFUNGAL AGENTS Pfizer Limited (GB) 1986-03-26 EP disclosed
EP-0166937-A2 Adrenergic compounds ABBOTT LABORATORIES (US) 1986-01-08 EP disclosed
US-4554242-A Method for processing color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-11-19 US disclosed
US-4540705-A Antidepressant imidazolines and related compounds STERLING DRUG INC. (US) 1985-09-10 US disclosed
US-4532331-A 1-Benzyl-2-aminomethyl imidazole derivatives SMITHKLINE BECKMAN CORPORATION (US) 1985-07-30 US disclosed
EP-0140640-A2 Blood substitute FISONS plc (GB) 1985-05-08 EP disclosed
US-4497949-A PHOTOTHERMOGRAPHY;COLOR FILMS;STORAGE STABILITY;ANTIFOGGING AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-02-05 US disclosed
EP-0125783-A1 Dopamine-beta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1984-11-21 EP disclosed
US-4483863-A Triazole antifungal agents PFIZER INC. (US) 1984-11-20 US disclosed
EP-0125033-A1 Dopamine-beta-hydroxylase inhibitors SMITHKLINE BECKMAN CORPORATION (US) 1984-11-14 EP disclosed
US-4482563-A HISTAMINE H2-ANTAGONIST SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1984-11-13 US disclosed
EP-0115400-A1 Triazole antifungal agents Pfizer Limited (GB) 1984-08-08 EP disclosed
US-4407808-A 2-Heterocyclic alkylamino-3-nitropyrroles SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1983-10-04 US disclosed
EP-0086043-A1 2-(Phenoxyalkyl) imidazoles as ectoparasiticides and anthelmintics Pfizer Limited (GB) 1983-08-17 EP disclosed
EP-0005985-B1 3-NITRO PYRROLE COMPOUNDS, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1983-04-27 EP disclosed
EP-0072608-A2 Process for the preparation of cephalosporin derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-02-23 EP disclosed
US-4353826-A ANTITUBERCULAR ANTIBIOTICS CIBA-GEIGY CORPORATION (US) 1982-10-12 US disclosed
US-4331668-A ANTIHISTAMINE, ANTAGONIST SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1982-05-25 US disclosed
US-4324792-A SKIN DISORDERS, HAY FEVER, ASTHMA GLAXO GROUP LIMITED (GB) 1982-04-13 US disclosed
US-4294973-A Process for the preparation of diacylated 4-imidazolin-2-ones BAYER AKTIENGESELLSCHAFT (DE) 1981-10-13 US disclosed
US-4282146-A Preparation of 1,2,4,5-tetrahydro-7-alkoxy-(and 7,8-dialkoxy)-3H,3-benzazepines and 3-substituted derivatives thereof from the corresponding phenethylamines PENNWALT CORPORATION (US) 1981-08-04 US disclosed
US-4261891-A BACTERICIDES, ANTITUBERCULAR AGENTS CIBA-GEIGY CORPORATION (US) 1981-04-14 US disclosed
US-4238494-A HISTAMINE H2-RECEPTOR ANTAGONIST SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-12-09 US disclosed
US-4238618-A Process for the preparation of diacylated 4-imidazolin-2-ones BAYER AKTIENGESELLSCHAFT (DE) 1980-12-09 US disclosed
EP-0005985-A1 3-Nitro pyrrole compounds, processes for preparing them and pharmaceutical compositions containing them SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-12-12 EP disclosed
US-4137268-A Method of preparing aminoacetaldehyde acetals by the hydrogenation of dialkoxyacetonitrile DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-4137268-A Method of preparing aminoacetaldehyde acetals by the hydrogenation of dialkoxyacetonitrile DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-4137268-A Method of preparing aminoacetaldehyde acetals by the hydrogenation of dialkoxyacetonitrile DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-4098783-A Dye substituted cyclic 1,3-sulfur-nitrogen compounds as dye image-forming materials in photography POLAROID CORPORATION (US) 1978-07-04 US disclosed
US-4005077-A DERIVATIVES OF RIFAMYCIN S OR SV CIBA-GEIGY CORPORATION (US) 1977-01-25 US disclosed
US-4002742-A 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor SCHERING CORPORATION (US) 1977-01-11 US disclosed
US-3985881-A 1(3,4,5-Trimethoxybenzamido methyl) tetrahydro isoquinoline derivatives and a process for their production MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-10-12 US disclosed
US-3952006-A Thiophene derivatives YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1976-04-20 US disclosed
US-3952006-A Thiophene derivatives YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1976-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080070867-A1 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases PPM1B, PPM1D, PTPRS LMNA 3553/4885THRB 653/4885ALDH1A1 3704/4885
US-20150368264-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS CPS1, SDHA, DHPS LMNA 2030/4885THRB 4294/4885ALDH1A1 883/4885
US-12091407-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof GLS, HMOX2, REN LMNA 2765/4885THRB 2082/4885ALDH1A1 1872/4885
US-20150328205-A1 2-AMINO-3-(IMIDAZOL-2-YL)-PYRIDIN-4-ONE DERIVATIVES AND THEIR USE AS VEGF RECEPTOR KINASE INHIBITORS KDR, FLT4, FLT1 LMNA 2922/4885THRB 753/4885ALDH1A1 1831/4885
US-20110003827-A1 HIV protease inhibiting compounds SERPINB1, HPN, DNPEP LMNA 3100/4885THRB 4644/4885ALDH1A1 2920/4885
US-20050025740-A1 Polyoxime compounds and their preparation PCBP1, PAM, OGFOD1 LMNA 2208/4885THRB 1492/4885ALDH1A1 4280/4885
US-20190345137-A1 SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS CHIA, CHIT1, AADAC LMNA 4612/4885THRB 1287/4885ALDH1A1 1830/4885
US-20200223866-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS CPS1, SDHA, DHPS LMNA 2030/4885THRB 4294/4885ALDH1A1 883/4885
US-20140179667-A1 ARYL AND HETEROARYL FUSED LACTAMS CCNY, MLX, NFXL1 LMNA 1563/4885THRB 1883/4885ALDH1A1 2245/4885
US-20160347760-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds UGT2B7, CYP3A43, CYP3A4 LMNA 1045/4885THRB 946/4885ALDH1A1 594/4885
US-20020072523-A1 Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same IL4, IL4I1, MSR1 LMNA 4706/4885THRB 2173/4885ALDH1A1 1556/4885
US-20050148623-A1 Prevent reproduct of aids virus SERPINB1, PRSS1, SERPINA3 LMNA 3063/4885THRB 4614/4885ALDH1A1 1209/4885
US-20220169641-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof GLS, HMOX2, REN LMNA 2765/4885THRB 2082/4885ALDH1A1 1872/4885
US-20110166169-A1 NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF HSP90AB2P, HSP90AB1, HSP90AA1 LMNA 4578/4885THRB 1186/4885ALDH1A1 1673/4885
US-11130753-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof GLS, HMOX2, REN LMNA 2765/4885THRB 2082/4885ALDH1A1 1872/4885
US-20110201604-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof HMOX2, HMOX1, PTGS2 LMNA 3326/4885THRB 2161/4885ALDH1A1 1757/4885
US-10287284-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof HMOX2, HMOX1, PTGS2 LMNA 3326/4885THRB 2161/4885ALDH1A1 1757/4885
US-20090012062-A1 Novel Substituted Pyrazinone Derivatives for Use in Mch-1 Mediated Diseases MCHR1, MCHR2, MC1R LMNA 3860/4885THRB 391/4885ALDH1A1 954/4885
US-20230312548-A1 SUBSTITUTE FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF GLS, HMOX2, REN LMNA 3422/4885THRB 2091/4885ALDH1A1 1697/4885
US-20070088051-A1 INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS MKI67, CCNT1, CCNA1 LMNA 1271/4885THRB 2107/4885ALDH1A1 410/4885
US-20160264549-A1 SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A) PDE9A, PDE10A, PDE6A LMNA 4194/4885THRB 1615/4885ALDH1A1 186/4885
US-20170233368-A1 ARYL AND HETEROARYL FUSED LACTAMS CCNY, MLX, NFXL1 LMNA 1563/4885THRB 1883/4885ALDH1A1 2245/4885
US-11649230-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof GLS, HMOX2, REN LMNA 2765/4885THRB 2082/4885ALDH1A1 1872/4885
US-20200148673-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof GOT2, GLS2, PYGL LMNA 2621/4885THRB 1484/4885ALDH1A1 491/4885
US-20040248900-A1 Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals CYP19A1, TBXAS1, CYP11B1 LMNA 820/4885THRB 534/4885ALDH1A1 453/4885
US-20150175572-A1 ARYL AND HETEROARYL FUSED LACTAMS CCNY, MLX, NFXL1 LMNA 1563/4885THRB 1883/4885ALDH1A1 2245/4885
US-20130023463-A1 HIV PROTEASE INHIBITING COMPOUNDS SERPINB1, HPN, DNPEP LMNA 3100/4885THRB 4644/4885ALDH1A1 2920/4885
US-20180022757-A1 SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS CPS1, SDHA, DHPS LMNA 2030/4885THRB 4294/4885ALDH1A1 883/4885
US-20020019343-A1 Antineoplastic conjugates of transferrin, albumin and polyethylene glycol TFRC, ALB, FOLR1 LMNA 3807/4885THRB 1186/4885ALDH1A1 2933/4885
US-20190194181-A1 Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof HMOX2, HMOX1, UACA LMNA 2940/4885THRB 2073/4885ALDH1A1 1046/4885
US-20150284405-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds UGT2B7, CYP3A43, CYP3A4 LMNA 1045/4885THRB 946/4885ALDH1A1 594/4885
US-20110184015-A1 NOVEL DERIVATIVES OF PYRROLOINDOLE WHICH ARE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF HSP90AB1, HSP90AB2P, HSP90AA1 LMNA 3855/4885THRB 2638/4885ALDH1A1 2129/4885
US-20050107360-A1 Bicyclic compounds MAOB, MAOA, XDH LMNA 751/4885THRB 952/4885ALDH1A1 630/4885
US-20200385370-A1 APPARATUS FOR REMOVING BAD ODOR FROM TOILET IRAK4, IRAK1, IRAK2 LMNA 4124/4885THRB 2394/4885ALDH1A1 828/4885
US-20150307487-A1 SMALL MOLECULES TARGETING REPEAT r(CGG) SEQUENCES HNRNPM, RBM39, FUS LMNA 943/4885THRB 1680/4885ALDH1A1 4710/4885
US-20190270751-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds UGT2B7, CYP3A43, CYP3A4 LMNA 1045/4885THRB 946/4885ALDH1A1 594/4885
US-20230381170-A1 METHOD FOR TREATING ALS/FTD THROUGH DEGRADATION OF RNA REPEAT EXPANSION RBM39, HNRNPC, HNRNPH3 LMNA 234/4885THRB 4381/4885ALDH1A1 4690/4885
US-20090163506-A1 Urea-compounds active as vanilloid receptor antagonists for the treatment of pain TRPV1, OPRL1, UTS2R LMNA 2498/4885THRB 1971/4885ALDH1A1 2656/4885
US-20090137597-A1 Novel quinoxalinone derivatives NDUFB1, NDUFB6, NDUFB7 LMNA 976/4885THRB 3593/4885ALDH1A1 975/4885
US-20100267672-A1 NOVEL COMPOUNDS OF REVERSE-TURN MIMETICS, METHOD FOR MANUFACTURING THE SAME AND USE THEREOF MCL1, THPO, FLT3 LMNA 781/4885THRB 318/4885ALDH1A1 3827/4885
US-20160235759-A1 Kappa Opioid Receptor Compounds OPRK1, OPRL1, OPRD1 LMNA 3939/4885THRB 249/4885ALDH1A1 1402/4885
US-20110053932-A1 Protein Kinase Inhibitors and Methods for Using Thereof BMX, FRK, FYN LMNA 3091/4885THRB 940/4885ALDH1A1 3388/4885
US-20060154915-A1 Substituted biaryl compounds as factor XIa inhibitors TFPI, F3, F12 LMNA 426/4885THRB 1210/4885ALDH1A1 4002/4885
US-20150158895-A1 SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A) PDE9A, PDE10A, PDE6A LMNA 4194/4885THRB 1615/4885ALDH1A1 186/4885
US-20150038507-A1 Antiprotozoal Compounds TREH, MPO, TBCA LMNA 1440/4885THRB 3017/4885ALDH1A1 390/4885
US-20200377511-A1 Bicyclic-Fused Heteroaryl or Aryl Compounds UGT2B7, CYP3A43, CYP3A4 LMNA 1045/4885THRB 946/4885ALDH1A1 594/4885
US-20150291592-A1 HEPATITIS C INHIBITOR COMPOUNDS HAVCR2, CD4, HAX1 LMNA 1423/4885THRB 1263/4885ALDH1A1 773/4885
US-20050159469-A1 HIV protease inhibiting compounds SERPINB1, HPN, DNPEP LMNA 3100/4885THRB 4644/4885ALDH1A1 2920/4885
US-10030011-B2 Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof HMOX2, HMOX1, PTGS2 LMNA 3326/4885THRB 2161/4885ALDH1A1 1757/4885
US-10793579-B2 Bicyclic-fused heteroaryl or aryl compounds UGT2B7, CYP3A43, CYP3A4 LMNA 1045/4885THRB 946/4885ALDH1A1 594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.