Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294857 | 0.69 | CCR1 (0.36) | NPC1 | |
| SCHEMBL22116851 | 0.69 | KDM4E (0.34) | ALDH1A1 | |
| SCHEMBL4408 | 0.68 | KDM4E (0.57) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30583086 | 0.67 | MAOA (0.54) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL28220033 | 0.67 | MAOA (0.54) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4467440 | 0.67 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17511855 | 0.66 | KDM4E (0.42) | ALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL10454827 | 0.65 | CYP2A6 (0.45) | — | |
| SCHEMBL7974002 | 0.65 | ALDH1A1 (0.37) | ALDH1A1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7790779 | 0.65 | KDM4E (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |