Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 0.30 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8565575 | 0.84 | ALDH1A1 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL8564785 | 0.83 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| SCHEMBL8562108 | 0.79 | AR (0.42) | CHRNB2CHRNA4KDM4EALDH1A1OPRK1 | |
| SCHEMBL8562175 | 0.76 | CYP19A1 (0.41) | KDM4EALDH1A1OPRK1TTR | |
| SCHEMBL8561344 | 0.75 | ACHE (0.39) | CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL27881083 | 0.73 | NOTUM (0.36) | ALDH1A1 | |
| SCHEMBL8562417 | 0.73 | GLS (0.46) | KDM4EALDH1A1OPRK1 | |
| SCHEMBL8564363 | 0.71 | LMNA (0.54) | KDM4EALDH1A1 | |
| SCHEMBL11676405 | 0.69 | TP53 (0.36) | — | |
| SCHEMBL9533477 | 0.69 | KDM4E (0.31) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5679674-A | ANALGESICS | SANKYO COMPANY, LIMITED (JP) | 1997-10-21 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| EP-0657443-A1 | OPTICALLY ACTIVE CARBOXAMIDE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |