Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 9/20 | 0.53 |
| ▸ | HTR3B | O95264 | 9/20 | 0.53 |
| ▸ | HTR3A | P46098 | 9/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 9/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 9/20 | 0.53 |
| ▸ | HTR2C | P28335 | 6/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570061 | 0.90 | HTR1A (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8564672 | 0.87 | HTR1A (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8566284 | 0.84 | DRD4 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569342 | 0.83 | DRD4 (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569105 | 0.83 | DRD2 (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8563463 | 0.82 | DRD2 (0.46) | HTR2CHTR1ADRD2DRD3HTR6 | |
| SCHEMBL8565134 | 0.82 | HTR1A (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8572094 | 0.81 | HTR1A (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565075 | 0.80 | DRD4 (0.53) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8569974 | 0.80 | ALDH1A1 (0.46) | HTR2CHTR1ADRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | claimed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | claimed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | claimed |
| JP-6340666-A | — | — | None | — | — | JP | disclosed |
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| JP-H06340666-A | NEW PYRROLOPYRAZINE COMPOUND, ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | ADIR | 1994-12-13 | — | — | JP | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |