Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.53 |
| ▸ | HTR3B | O95264 | 5/20 | 0.53 |
| ▸ | HTR3A | P46098 | 5/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566350 | 0.88 | KDM4E (0.52) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8879183 | 0.85 | KDM4E (0.52) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8564672 | 0.83 | HTR1A (0.53) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8563754 | 0.82 | HTR3E (0.53) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8565559 | 0.80 | DRD4 (0.45) | HTR1AKDM4EMAPTDRD4DRD3 | |
| SCHEMBL8570061 | 0.79 | HTR1A (0.54) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8570680 | 0.77 | CCR1 (0.39) | SIGMAR1DRD4DRD3 | |
| SCHEMBL8563463 | 0.76 | DRD2 (0.46) | HTR1AHTR2CKDM4EMAPTSIGMAR1 | |
| SCHEMBL8572094 | 0.76 | HTR1A (0.48) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL27666200 | 0.76 | KDM4E (0.60) | HTR1AHTR2CHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |