Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.42 |
| ▸ | HTR3B | O95264 | 6/20 | 0.42 |
| ▸ | HTR3A | P46098 | 6/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563754 | 0.87 | HTR3E (0.53) | HTR1AHTR2CDRD4DRD2HTR3E | |
| SCHEMBL8570061 | 0.86 | HTR1A (0.54) | HTR1AHTR2CDRD4DRD2HTR3E | |
| SCHEMBL8565134 | 0.83 | HTR1A (0.54) | HTR1AHTR2CSIGMAR1DRD4HTR3E | |
| SCHEMBL8880176 | 0.82 | HTR7 (0.50) | HTR1AHTR2CSIGMAR1DRD4DRD2 | |
| SCHEMBL8563463 | 0.77 | DRD2 (0.46) | HTR1AHTR2CSIGMAR1DRD2DRD3 | |
| SCHEMBL8572094 | 0.76 | HTR1A (0.48) | HTR1AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL8566284 | 0.76 | DRD4 (0.54) | HTR1AHTR2CDRD4DRD2HTR3E | |
| SCHEMBL8569567 | 0.76 | KDM4E (0.47) | HTR1AHTR2CDRD2HTR3EHTR3B | |
| SCHEMBL8565559 | 0.76 | DRD4 (0.45) | HTR1ADRD4DRD2POLBDRD3 | |
| SCHEMBL8569342 | 0.76 | DRD4 (0.51) | HTR1AHTR2CSIGMAR1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |