Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557382 | 0.85 | AVPR2 (0.50) | NAMPTHPGDAVPR1AAVPR2OXTR | |
| SCHEMBL8561675 | 0.85 | NAMPT (0.50) | NAMPTALDH1A1AVPR1A | |
| SCHEMBL7349542 | 0.84 | AVPR1A (0.65) | AVPR1APOLB | |
| SCHEMBL8562680 | 0.84 | ALDH1A1 (0.59) | NAMPTALDH1A1HPGDAVPR1AAVPR2 | |
| SCHEMBL8564664 | 0.82 | NAMPT (0.47) | NAMPTHPGDAVPR1AAVPR2OXTR | |
| SCHEMBL8563056 | 0.82 | ALDH1A1 (0.48) | NAMPTALDH1A1HPGDMAPTAVPR1A | |
| SCHEMBL8315540 | 0.79 | HSD11B1 (0.48) | NAMPTALDH1A1MAPTHSD11B1NPC1 | |
| SCHEMBL7332888 | 0.79 | AVPR2 (0.65) | NAMPTALDH1A1HPGDAVPR1AAVPR2 | |
| SCHEMBL8562670 | 0.77 | AVPR1A (0.60) | AVPR1AAVPR2OXTR | |
| SCHEMBL8560388 | 0.77 | AVPR1A (0.60) | NAMPTAVPR1AAVPR2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |