Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATIC | P31939 | 3/20 | 0.48 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.48 |
| ▸ | GART | P22102 | 2/20 | 0.48 |
| ▸ | EP300 | Q09472 | 7/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563902 | 0.95 | TLR7 (0.50) | ATICSHMT1SHMT2GARTEP300 | |
| SCHEMBL8563771 | 0.80 | TLR7 (0.45) | ATICSHMT1SHMT2GARTEP300 | |
| SCHEMBL8563875 | 0.77 | ATIC (0.74) | ATICSHMT1SHMT2GART | |
| SCHEMBL8563883 | 0.77 | ATIC (0.74) | ATICSHMT1SHMT2GART | |
| SCHEMBL8564667 | 0.75 | DHFR (0.38) | TLR7ALDH1A1MAPTKMT2A | |
| SCHEMBL9343568 | 0.73 | CYP2D6 (0.55) | EP300RARBMEN1ALDH1A1RARA | |
| SCHEMBL9001785 | 0.72 | TLR7 (0.44) | ATICSHMT1SHMT2GARTEP300 | |
| SCHEMBL8570466 | 0.72 | DHFR (0.39) | TLR7ALDH1A1MAPTKMT2A | |
| SCHEMBL8567736 | 0.72 | ATIC (0.66) | ATICSHMT1SHMT2GART | |
| SCHEMBL8567743 | 0.72 | ATIC (0.66) | ATICSHMT1SHMT2GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530579-B1 | Condensed pyrimidine derivatives antitumor agents | EISAI CO LTD (JP) | 1998-11-11 | — | — | EP | disclosed |
| US-5554615-A | ANTITUMOR | EISAI CO., LTD. (JP) | 1996-09-10 | — | — | US | disclosed |
| EP-0530579-A1 | Condensed pyrimidine derivatives antitumor agents | Eisai Co., Ltd. (JP) | 1993-03-10 | — | — | EP | disclosed |